Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment

Ni, Can, Zhou, Jing, Kong, Na, Bian, Tianying, Zhang, Yangheng, Huang, Xiaofeng, Xiao, Yin, Yang, Wenrong and Yan, Fuhua 2019, Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment, Biomaterials, vol. 206, pp. 115-132, doi: 10.1016/j.biomaterials.2019.03.039.

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Title Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment
Author(s) Ni, Can
Zhou, Jing
Kong, Na
Bian, Tianying
Zhang, Yangheng
Huang, Xiaofeng
Xiao, Yin
Yang, WenrongORCID iD for Yang, Wenrong orcid.org/0000-0001-8815-1951
Yan, Fuhua
Journal name Biomaterials
Volume number 206
Start page 115
End page 132
Total pages 18
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2019-06
ISSN 1878-5905
Keyword(s) Gold nanoparticles
Inflammatory microenvironment
Macrophages
Periodontal ligament cells
Periodontal regeneration
Periodontitis
Science & Technology
Technology
Engineering, Biomedical
Materials Science, Biomaterials
Engineering
Materials Science
MESENCHYMAL STEM-CELLS
NF-KAPPA-B
PROMOTE OSTEOGENIC DIFFERENTIATION
TOLL-LIKE RECEPTORS
CELLULAR UPTAKE
TNF-ALPHA
OSTEOBLAST DIFFERENTIATION
CONDITIONED MEDIUM
SIGNALING PATHWAY
BONE LOSS
Summary The regeneration of lost periodontal apparatus in periodontitis treatment remains a clinical challenge due to the limited regenerative capacity of cementum, periodontal ligament and alveolar bone in periodontitis condition. For periodontal tissue regeneration, it is essential to regulate the inflammatory response and the subsequent differentiation of periodontal cells under the condition due to the infectious nature of the disease. In this study, it was noted that 45 nm gold nanoparticles (AuNPs) could exhibit significant anti-inflammatory effect and improve the periodontal inflammatory microenvironment via regulating inflammatory and regenerative cytokine production and modulating macrophage polarization, subsequently affect the differentiation of human periodontal ligament cells (hPDLCs). With the addition of direct effects of AuNPs on hPDLCs, the periodontal tissue differentiation capacity of hPDLCs in LPS-activated inflammatory macrophage-hPDLCs coculture system was significantly enhanced by the interaction between AuNPs-conditioned macrophage and AuNPs-stimulated hPDLCs. The potential therapeutic application of AuNPs in periodontal tissue regeneration and periodontitis treatment was investigated using both rat fenestration and ligature-induced periodontitis models. It was found that the treatment of 45 AuNPs showed significantly increased newly-formed periodontal attachment, bone and cementum in periodontal defect and less tissue destruction in the progression of periodontitis. This study demonstrated that 45 nm AuNPs could not only directly modulate hPDLCs, but also regulate the early inflammatory response of periodontal tissues via the regulation of macrophage phenotypes, therefore, generate a microenvironment with constraint inflammatory cytokine levels and reparative cytokines such as bone morphogenetic protein-2 (BMP-2), leading to PDLC differentiation, periodontal tissue regeneration and the prevention of periodontitis progression.
Language eng
DOI 10.1016/j.biomaterials.2019.03.039
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120770

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