To protect and to preserve: novel preservation strategies for extracellular vesicles Kusuma, Gina D., Barabadi, Mehri, Tan, Jean L., Morton, David A. V., Frith, Jessica E. and Lim, Rebecca 2018, To protect and to preserve: novel preservation strategies for extracellular vesicles, Frontiers in pharmacology, vol. 9, doi: 10.3389/fphar.2018.01199. Attached Files Name Description MIMEType Size Downloads Title To protect and to preserve: novel preservation strategies for extracellular vesicles Author(s) Kusuma, Gina D. Barabadi, Mehri Tan, Jean L. Morton, David A. V. Frith, Jessica E. Lim, Rebecca Journal name Frontiers in pharmacology Volume number 9 Article ID 1199 Total pages 17 Publisher Frontiers Media Place of publication Lausanne, Switzerland Publication date 2018-10 ISSN 1663-9812 Keyword(s) biologics biomaterials cryopreservation exosomes extracellular vesicles nanomedicine regenerative medicine Summary Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by stem cells exert similar therapeutic effects and these have been proposed as an alternative to cell therapies. EV-mediated delivery is an effective and efficient system of cell-to-cell communication which can confer therapeutic benefits to their target cells. EVs have been shown to promote tissue repair and regeneration in various animal models such as, wound healing, cardiac ischemia, diabetes, lung fibrosis, kidney injury, and many others. Given the unique attributes of EVs, considerable thought must be given to the preservation, formulation and cold chain strategies in order to effectively translate exciting preclinical observations to clinical and commercial success. This review summarizes current understanding around EV preservation, challenges in maintaining EV quality, and also bioengineering advances aimed at enhancing the long-term stability of EVs. Language eng DOI 10.3389/fphar.2018.01199 Field of Research 1115 Pharmacology and Pharmaceutical Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2018, The Authors Persistent URL http://hdl.handle.net/10536/DRO/DU:30121198 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Engineering Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 01 May 2019, 16:24:07 EST Thu, 02 May 2019, 05:01:04 EST Thu, 02 May 2019, 06:04:08 EST Mon, 06 May 2019, 10:52:41 EST Mon, 06 May 2019, 11:05:55 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 2 times in Scopus Search Google Scholar Access Statistics: 71 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 01 May 2019, 16:24:07 EST

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