To protect and to preserve: novel preservation strategies for extracellular vesicles
Kusuma, Gina D., Barabadi, Mehri, Tan, Jean L., Morton, David A. V., Frith, Jessica E. and Lim, Rebecca 2018, To protect and to preserve: novel preservation strategies for extracellular vesicles, Frontiers in pharmacology, vol. 9, doi: 10.3389/fphar.2018.01199.
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To protect and to preserve: novel preservation strategies for extracellular vesicles
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by stem cells exert similar therapeutic effects and these have been proposed as an alternative to cell therapies. EV-mediated delivery is an effective and efficient system of cell-to-cell communication which can confer therapeutic benefits to their target cells. EVs have been shown to promote tissue repair and regeneration in various animal models such as, wound healing, cardiac ischemia, diabetes, lung fibrosis, kidney injury, and many others. Given the unique attributes of EVs, considerable thought must be given to the preservation, formulation and cold chain strategies in order to effectively translate exciting preclinical observations to clinical and commercial success. This review summarizes current understanding around EV preservation, challenges in maintaining EV quality, and also bioengineering advances aimed at enhancing the long-term stability of EVs.
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.