To protect and to preserve: novel preservation strategies for extracellular vesicles

Kusuma, Gina D., Barabadi, Mehri, Tan, Jean L., Morton, David A. V., Frith, Jessica E. and Lim, Rebecca 2018, To protect and to preserve: novel preservation strategies for extracellular vesicles, Frontiers in pharmacology, vol. 9, doi: 10.3389/fphar.2018.01199.

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Title To protect and to preserve: novel preservation strategies for extracellular vesicles
Author(s) Kusuma, Gina D.
Barabadi, Mehri
Tan, Jean L.
Morton, David A. V.
Frith, Jessica E.
Lim, Rebecca
Journal name Frontiers in pharmacology
Volume number 9
Article ID 1199
Total pages 17
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2018-10
ISSN 1663-9812
Keyword(s) biologics
biomaterials
cryopreservation
exosomes
extracellular vesicles
nanomedicine
regenerative medicine
Summary Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by stem cells exert similar therapeutic effects and these have been proposed as an alternative to cell therapies. EV-mediated delivery is an effective and efficient system of cell-to-cell communication which can confer therapeutic benefits to their target cells. EVs have been shown to promote tissue repair and regeneration in various animal models such as, wound healing, cardiac ischemia, diabetes, lung fibrosis, kidney injury, and many others. Given the unique attributes of EVs, considerable thought must be given to the preservation, formulation and cold chain strategies in order to effectively translate exciting preclinical observations to clinical and commercial success. This review summarizes current understanding around EV preservation, challenges in maintaining EV quality, and also bioengineering advances aimed at enhancing the long-term stability of EVs.
Language eng
DOI 10.3389/fphar.2018.01199
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30121198

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