Weight change and cardiometabolic outcomes in postpartum women with history of gestational diabetes

Lim, Siew, Versace, Vincent L, O'Reilly, Sharleen, Janus, Edward and Dunbar, James 2019, Weight change and cardiometabolic outcomes in postpartum women with history of gestational diabetes, Nutrients, vol. 11, no. 4, pp. 1-13, doi: 10.3390/nu11040922.

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Title Weight change and cardiometabolic outcomes in postpartum women with history of gestational diabetes
Author(s) Lim, SiewORCID iD for Lim, Siew orcid.org/0000-0002-5333-6451
Versace, Vincent LORCID iD for Versace, Vincent L orcid.org/0000-0002-8514-1763
O'Reilly, SharleenORCID iD for O'Reilly, Sharleen orcid.org/0000-0003-3547-6634
Janus, Edward
Dunbar, JamesORCID iD for Dunbar, James orcid.org/0000-0003-0866-4365
Journal name Nutrients
Volume number 11
Issue number 4
Article ID 922
Start page 1
End page 13
Total pages 13
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-04
ISSN 2072-6643
2072-6643
Keyword(s) diabetes prevention program
gestational diabetes
postpartum
weight gain
weight loss
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
Summary Weight gain after childbirth is a significant risk factor for type 2 diabetes (T2DM) development after gestational diabetes mellitus (GDM). The level of weight loss achieved in diabetes prevention programs for women after GDM is often low but its effects on the cardiometabolic risk are not known. In a secondary analysis of a diabetes prevention program in postpartum women with history of gestational diabetes, we evaluated the effect of weight change on the cardiometabolic outcomes at 1-year follow-up. Of the 284 women randomized to the intervention arm, 206 with the final outcome measurements were included in the analyses. Participants were categorized into weight loss (>2 kg, n = 74), weight stable (±2 kg, n = 74) or weight gain (>2 kg, n = 58) groups. The weight loss group had significantly greater decrease in glycated hemoglobin (HbA1c) than the weight gain group (-0.1 + 0.4% vs. 0 + 0.4%, p = 0.049). The weight loss group had significantly greater decrease in total cholesterol and low-density lipoprotein cholesterol cholesterol than the other two groups (p < 0.05). The weight gain group had significantly greater increase in triglyceride and triglyceride:high-density lipoprotein cholesterol ratio compare with the other groups (p < 0.01). Overall, a small amount of weight loss and prevention of further weight gain was beneficial to the cardiometabolic outcomes of postpartum women after GDM.
Language eng
DOI 10.3390/nu11040922
Field of Research 1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, the authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30121206

Document type: Journal Article
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