Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial

Kavanagh, Bianca, Williams, Lana, Berk, Michael, Turner, Alyna, Jackson, Henry J., Mohebbi, Mohammadreza, Kanchanatawan, Buranee, Ashton, Melanie, Ng, Chee H., Maes, Michael, Berk, Lesley, Malhi, Gin S., Dowling, Nathan, Singh, Ajeet B. and Dean, Olivia 2019, Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial, Brazilian journal of psychiatry, doi: 10.1590/1516-4446-2018-0308.

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Title Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial
Author(s) Kavanagh, BiancaORCID iD for Kavanagh, Bianca
Williams, LanaORCID iD for Williams, Lana
Berk, MichaelORCID iD for Berk, Michael
Turner, AlynaORCID iD for Turner, Alyna
Jackson, Henry J.
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza
Kanchanatawan, Buranee
Ashton, MelanieORCID iD for Ashton, Melanie
Ng, Chee H.
Maes, Michael
Berk, Lesley
Malhi, Gin S.
Dowling, Nathan
Singh, Ajeet B.
Dean, OliviaORCID iD for Dean, Olivia
Journal name Brazilian journal of psychiatry
Total pages 8
Publisher Associacao Brasileira de Psiquiatria
Place of publication Sao Paulo, Brazil
Publication date 2019-05-16
ISSN 1516-4446
Summary OBJECTIVE: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD). METHODS: Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression - Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD (dichotomized factor [≥ 3] or continuous measure) on the outcome measures-treatment group correlation. RESULTS: PD was identified in 69% of the sample. After adjusting for age, sex, and baseline scores for each of the outcome measures, there was no significant difference between participants with and without PD on week 12 scores for any of the outcome measures (all p > 0.14). CONCLUSION: In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD. CLINICAL TRIAL REGISTRATION: ACTRN12612000283875.
Notes In Press
Language eng
DOI 10.1590/1516-4446-2018-0308
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
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