Improving medication adherence in adult kidney transplantation (IMAKT): a pilot randomised controlled trial

Low, Jac Kee, Manias, Elizabeth, Crawford, Kimberley, Walker, Rowan, Mulley, William R, Toussaint, Nigel D, Dooley, Michael, Kennedy, Elaine, Smith, Catherine L, Nalder, Michelle, Yip, Doris and Williams, Allison 2019, Improving medication adherence in adult kidney transplantation (IMAKT): a pilot randomised controlled trial, Scientific reports, vol. 9, pp. 1-8, doi: 10.1038/s41598-019-44002-y.

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Title Improving medication adherence in adult kidney transplantation (IMAKT): a pilot randomised controlled trial
Author(s) Low, Jac KeeORCID iD for Low, Jac Kee
Manias, ElizabethORCID iD for Manias, Elizabeth
Crawford, Kimberley
Walker, Rowan
Mulley, William R
Toussaint, Nigel D
Dooley, Michael
Kennedy, Elaine
Smith, Catherine L
Nalder, Michelle
Yip, Doris
Williams, Allison
Journal name Scientific reports
Volume number 9
Article ID 7734
Start page 1
End page 8
Total pages 8
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2019-05-22
ISSN 2045-2322
Keyword(s) End-stage renal disease
Patient education
Science & Technology
Multidisciplinary Sciences
Summary Resources to support long-term medication adherence in kidney transplantation are limited. This study aimed to determine the efficacy of an intervention designed for kidney transplant recipients to enhance medication adherence. A single-blind, multi-site, 12-month pilot randomised controlled trial was conducted at all five public hospitals providing adult kidney transplantation in Victoria, Australia. Participants were recruited at 4 to 6 weeks post-transplantation. Thirty-five participants were randomly assigned to a 3-month intervention, involving a face-to-face meeting (a medication review and a consumer-centred video) and health coaching every two weeks. Thirty-six were randomised to receive usual care. All participants were followed for nine months post-intervention. There were no differences in adherence between groups measured by Medication Event Monitoring System (MEMS), however, it was underutilised by 42% of participants. Based on the self-reported Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©) score, the percentage of adherent participants decreased significantly between baseline and 3 to 12 months in the control group (p-values < 0.001) whilst the percentage of adherent participants in the intervention group remained constant over time. No group differences were detected in other outcomes. Due to the complex medication regimen, developing and testing a medication adherence intervention is difficult in kidney transplantation.
Language eng
DOI 10.1038/s41598-019-44002-y
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Author(s)
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Document type: Journal Article
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School of Nursing and Midwifery
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