The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation

Dhar, Poshmaal and McAuley, Julie 2019, The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation, Frontiers in cellular and infection microbiology, vol. 9, pp. 1-8, doi: 10.3389/fcimb.2019.00117.

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Title The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation
Author(s) Dhar, PoshmaalORCID iD for Dhar, Poshmaal orcid.org/0000-0002-2842-007X
McAuley, Julie
Journal name Frontiers in cellular and infection microbiology
Volume number 9
Article ID 117
Start page 1
End page 8
Total pages 8
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2019-04
ISSN 2235-2988
Keyword(s) MUC1
Helicobacter pylori
Campylobacter jejuni
influenza A virus
Streptococcus pneumoniae
Pseudomonas aeruginosa
toll-like receptor
NLRP3-inflammasome
Science & Technology
Life Sciences & Biomedicine
Immunology
Microbiology
Summary This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The family of cell surface (cs-) mucins are constitutively expressed at the cell surface by nearly all epithelial cells, beneath the gel-mucin layer. All cs-mucin family members have structural features that enable them to act as a releasable decoy barrier to mucosal pathogens, by providing ligands for pathogen binding and the ability to shed the bound extracellular domain. Due to the towering structure of cs-mucins at the surface, binding of mucosal pathogens can also sterically block binding to underlying cellular receptors. The cytoplasmic tail domain of cs-mucins are capable of initiating signal transduction cascades and due to their conservation across species, may play an important biological role in cellular signaling. MUC1 is one of the most extensively studied of the cs-mucin family. With respect to its physiological function in the mucosal environment, MUC1 has been demonstrated to play a dynamic role in protection of the host from infection by a wide variety of pathogens and to regulate inflammatory responses to infection. This review briefly summarizes the current knowledge and new findings regarding the structural features relating to the function of MUC1, its role as a protective barrier against pathogen invasion and mechanisms by which this cs-mucin regulates inflammation.
Language eng
DOI 10.3389/fcimb.2019.00117
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Dhar and McAuley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30122845

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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