The potential of carnosine in brain-related disorders: a comprehensive review of current evidence

Schön, Martin, Mousa, Aya, Berk, Michael, Chia, Wern L, Ukropec, Jozef, Majid, Arshad, Ukropcová, Barbara and de Courten, Barbara 2019, The potential of carnosine in brain-related disorders: a comprehensive review of current evidence, Nutrients, vol. 11, no. 6, pp. 1-26, doi: 10.3390/nu11061196.

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Title The potential of carnosine in brain-related disorders: a comprehensive review of current evidence
Author(s) Schön, Martin
Mousa, Aya
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Chia, Wern L
Ukropec, Jozef
Majid, Arshad
Ukropcová, Barbara
de Courten, Barbara
Journal name Nutrients
Volume number 11
Issue number 6
Start page 1
End page 26
Total pages 26
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-06
ISSN 2072-6643
Keyword(s) carnosine
L-histidine
β-alanine
brain
cognition
treatment
psychiatry
neurology
nervous system
-alanine
Summary Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensive overview of the role of carnosine in neurological, neurodevelopmental, neurodegenerative, and psychiatric disorders, summarizing current evidence from cell, animal, and human cross-sectional, longitudinal studies, and randomized controlled trials.
Language eng
DOI 10.3390/nu11061196
Indigenous content off
Field of Research 1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, the authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30122848

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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