A comprehensive review of the ¹H-MRS metabolite spectrum in autism spectrum disorder

Ford, Talitha C. and Crewther, David P. 2016, A comprehensive review of the ¹H-MRS metabolite spectrum in autism spectrum disorder, Frontiers in molecular neuroscience, vol. 9, pp. 1-27, doi: 10.3389/fnmol.2016.00014.

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Title A comprehensive review of the ¹H-MRS metabolite spectrum in autism spectrum disorder
Author(s) Ford, Talitha C.ORCID iD for Ford, Talitha C. orcid.org/0000-0001-5400-2659
Crewther, David P.
Journal name Frontiers in molecular neuroscience
Volume number 9
Article ID 14
Start page 1
End page 27
Total pages 27
Publisher Frontiers
Place of publication Lausanne, Switzerland
Publication date 2016-03
ISSN 1662-5099
Keyword(s) 1H-MRS
autism spectrum disorder
brain metabolites
phenotype correlates
review
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
H-1-MRS
MAGNETIC-RESONANCE-SPECTROSCOPY
HIGH-FUNCTIONING AUTISM
PROTON MR SPECTROSCOPY
ASPERGER-SYNDROME
HUMAN BRAIN
COUPLING-CONSTANTS
PREFRONTAL CORTEX
CHEMICAL-SHIFTS
GLUTAMINE CYCLE
YOUNG-CHILDREN
Summary Neuroimaging studies of neuropsychiatric behavior biomarkers across spectrum disorders are typically based on diagnosis, thus failing to account for the heterogeneity of multi-dimensional spectrum disorders such as autism (ASD). Control group trait phenotypes are also seldom reported. Proton magnetic resonance spectroscopy ((1)H-MRS) measures the abundance of neurochemicals such as neurotransmitters and metabolites and hence can probe disorder phenotypes at clinical and sub-clinical levels. This detailed review summarizes and critiques the current (1)H-MRS research in ASD. The literature reports reduced N-acetylaspartate (NAA), glutamate and glutamine (Glx), γ-aminobutyric acid (GABA), creatine and choline, and increased glutamate for children with ASD. Adult studies are few and results are inconclusive. Overall, the literature has several limitations arising from differences in (1)H-MRS methodology and sample demographics. We argue that more consistent methods and greater emphasis on phenotype studies will advance understanding of underlying cortical metabolite disturbance in ASD, and the detection, diagnosis, and treatment of ASD and other multi-dimensional psychiatric disorders.
Language eng
DOI 10.3389/fnmol.2016.00014
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016 Ford and Crewther
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30123162

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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