White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids

Vijayakumar, Nandita, Bartholomeusz, Cali, Whitford, Thomas, Hermens, Daniel F., Nelson, Barnaby, Rice, Simon, Whittle, Sarah, Pantelis, Christos, McGorry, Patrick, Schäfer, Miriam R. and Amminger, G. Paul 2016, White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids, BMC psychiatry, vol. 16, no. 1, doi: 10.1186/s12888-016-0932-4.

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Title White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Author(s) Vijayakumar, NanditaORCID iD for Vijayakumar, Nandita orcid.org/0000-0002-5622-9547
Bartholomeusz, Cali
Whitford, Thomas
Hermens, Daniel F.
Nelson, Barnaby
Rice, Simon
Whittle, Sarah
Pantelis, Christos
McGorry, Patrick
Schäfer, Miriam R.
Amminger, G. Paul
Journal name BMC psychiatry
Volume number 16
Issue number 1
Article ID 287
Total pages 11
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2016-08-11
ISSN 1471-244X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Psychiatry
Ultra-high risk
Psychosis
White matter
Polyunsaturated fatty acids
Youth
1ST-EPISODE SCHIZOPHRENIA
BRAIN-DEVELOPMENT
CNS MYELIN
DIFFUSION
ABNORMALITIES
SYMPTOMS
ONSET
STATE
OMEGA-3-FATTY-ACIDS
OLIGODENDROCYTE
Summary © 2016 The Author(s). Background: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain prior to the emergence of clinical symptoms. Recent evidence from neuroimaging studies using techniques such as diffusion tensor imaging has identified white matter abnormalities that are suggestive of disrupted brain myelination and neuronal connectivity. Identifying whether such effects exist in individuals at high risk for developing psychosis may help with prevention and early intervention strategies. In addition, there is preliminary evidence for a role of lipid biology in the onset of psychosis, along with well-established evidence of its role in myelination of white matter tracts. As such, this article synthesises the literature on polyunsaturated fatty acids (PUFAs) in myelination and schizophrenia, hypothesizing that white matter abnormalities may potentially mediate the relationship between PUFAs and schizophrenia. Methods: Diffusion tensor imaging studies were identified through a systematic search of existing literature. Studies examined white matter integrity in ultra-high risk (UHR) samples, as assessed using structured diagnostic interviews. Data was extracted and summarised as a narrative review. Results: Twelve studies met inclusion criteria, and findings identified reduced fractional anisotropy and higher diffusivity. Although the exact location of abnormalities remains uncertain, fronto-temporal and fronto-limbic connections, including the superior longitudinal and uncinate fasiculus, cingulum, and corpus callosum appear to be implicated. Because of preliminary evidence suggesting lipid biology may be relevant for the onset of psychosis, a discussion is provided of the role of polyunsaturated fatty acids (PUFAs) in myelination and risk for psychosis. Conclusions: While the function of PUFAs in myelination is well-established, there is growing evidence of reduced PUFA concentration in UHR samples, highlighting the need for research to examine the relationship between PUFA and white matter integrity in high-risk samples and age-matched healthy controls. Such investigations will help to better understand the pathophysiology of the disorder, and potentially assist in the development of novel treatment and early intervention strategies.
Language eng
DOI 10.1186/s12888-016-0932-4
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30123609

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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