Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology

Whittle, Sarah, Bartholomeusz, Cali, Yücel, Murat, Dennison, Meg, Vijayakumar, Nandita and Allen, Nicholas B. 2014, Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology, Social cognitive and affective neuroscience, vol. 9, no. 2, pp. 232-239, doi: 10.1093/scan/nss126.

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Title Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology
Author(s) Whittle, Sarah
Bartholomeusz, Cali
Yücel, Murat
Dennison, Meg
Vijayakumar, NanditaORCID iD for Vijayakumar, Nandita orcid.org/0000-0002-5622-9547
Allen, Nicholas B.
Journal name Social cognitive and affective neuroscience
Volume number 9
Issue number 2
Start page 232
End page 239
Total pages 8
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2014-02
ISSN 1749-5024
1749-5024
Keyword(s) Science & Technology
Social Sciences
Life Sciences & Biomedicine
Neurosciences
Psychology
Psychology, Experimental
Neurosciences & Neurology
gyrification
temperament
orbitofrontal cortex
risk
adolescence
OBSESSIVE-COMPULSIVE DISORDER
BRAIN SEGMENTATION
VOLUME REDUCTION
SEX-DIFFERENCES
CORTEX
SCHIZOPHRENIA
EMOTION
ANXIETY
MRI
THICKNESS
Summary There are marked individual differences in the pattern of cortical (sulcogyral) folding in the orbitofrontal cortex (OFC), and there is a growing literature suggesting that these individual differences are associated with risk for psychotic disorders. To date, however, no study has investigated whether OFC folding patterns are associated with broader risk factors relevant to a range of psychopathology. This study helps address this knowledge gap by examining whether OFC sulcogyral folding patterns are associated with putative risk factors, specifically affective temperament and psychiatric symptoms, in a large community sample (N = 152) of adolescents. Results showed that the most common pattern of folding ('Type I', marked by discontinuity of the medial orbital sulcus and continuity of the lateral orbital sulcus) was associated with low levels of Surgency, high levels of Negative Affectivity (in girls) and higher depressive symptoms. This pattern was also associated with reduced thickness of OFC gray matter. Overall, the findings, combined with previous work, suggest some specificity of neurodevelopmental risk for different types of psychopathology. Thus, these results have the potential to inform the early identification of at-risk individuals. © The Author (2012).
Language eng
DOI 10.1093/scan/nss126
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30123628

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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