To see or not to see: a systematic review of the importance of human ocular surface cytokine biosignatures in ocular allergy

Aydin, Esrin, Gokhale, Moneisha, Azizoglu, Serap and Suphioglu, Cenk 2019, To see or not to see: a systematic review of the importance of human ocular surface cytokine biosignatures in ocular allergy, Cells, vol. 8, no. 6, pp. 1-12, doi: 10.3390/cells8060620.

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Title To see or not to see: a systematic review of the importance of human ocular surface cytokine biosignatures in ocular allergy
Author(s) Aydin, Esrin
Gokhale, Moneisha
Azizoglu, SerapORCID iD for Azizoglu, Serap orcid.org/0000-0003-3420-4098
Suphioglu, CenkORCID iD for Suphioglu, Cenk orcid.org/0000-0003-0101-0668
Journal name Cells
Volume number 8
Issue number 6
Article ID 620
Start page 1
End page 12
Total pages 12
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-06
ISSN 2073-4409
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Cell Biology
Ocular allergy
Allergy
Keratoconus
Cytokine
Biosignature
Biomarker
Immunoblot
Contact lens wear
Summary Cytokines are key cell signalling proteins in a number of immune and homeostatic pathways of the human body. In particular, they mediate intracellular mechanisms of allergy on the ocular surface by triggering cellular responses that result in typical physiological ocular allergy symptoms, such as itchiness, watery eyes, irritation, and swelling. Given the recent research focus in optometry on the aetiology of corneal ectasia subtypes like keratoconus, there is an increasing need for the development of new clinical diagnostic methods. An increasing trend is evident among recent publications in cytokine studies, whereby the concentrations of cytokines in healthy and disease states are compared to derive a specific cytokine profile for that disease referred to as ‘biosignatures’. Biosignatures have diagnostic applications in ocular allergy as a cheap, non-invasive alternative to current techniques like IgE antibody testing and skin prick tests. Cytokine detection from tear samples collected via microcapillary flow can be analysed either by enzyme-linked immunosorbent assays (ELISA), multiplex magnetic bead assays, or immunoblot assays. Characterising patient hypersensitivities through diagnostic tests is the first step to managing exposure to triggers. Investigating cytokine biosignatures in ocular allergy and their links to physiology are imperative and will be the focus of this systematic review article.
Language eng
DOI 10.3390/cells8060620
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, the authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30124590

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