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Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention

Johnson, Katherine A., Robertson, Ian H., Kelly, Simon P., Silk, Timothy J., Barry, Edwina, Dáibhis, Aoife, Watchorn, Amy, Keavey, Michelle, Fitzgerald, Michael, Gallagher, Louise, Gill, Michael and Bellgrove, Mark A. 2007, Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention, Neuropsychologia, vol. 45, no. 10, pp. 2234-2245, doi: 10.1016/j.neuropsychologia.2007.02.019.

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Title Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention
Author(s) Johnson, Katherine A.
Robertson, Ian H.
Kelly, Simon P.
Silk, Timothy J.ORCID iD for Silk, Timothy J. orcid.org/0000-0002-7290-512X
Barry, Edwina
Dáibhis, Aoife
Watchorn, Amy
Keavey, Michelle
Fitzgerald, Michael
Gallagher, Louise
Gill, Michael
Bellgrove, Mark A.
Journal name Neuropsychologia
Volume number 45
Issue number 10
Start page 2234
End page 2245
Total pages 12
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2007
ISSN 0028-3932
Keyword(s) Science & Technology
Social Sciences
Life Sciences & Biomedicine
Behavioral Sciences
Neurosciences
Psychology, Experimental
Neurosciences & Neurology
Psychology
response time
fast Fourier transform
variability
arousal
response inhibition
executive function
DEFICIT-HYPERACTIVITY-DISORDER
ANTERIOR CINGULATE CORTEX
DEFICIT/HYPERACTIVITY DISORDER
RESPONSE VARIABILITY
DIAGNOSTIC INTERVIEW
DOPAMINE-TRANSPORTER
SPECTRUM DISORDERS
INHIBITORY CONTROL
ASPERGER-SYNDROME
Summary Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal circuits. We probed executive function in these disorders using a sustained attention task with a validated brain-behaviour basis. Twenty-three children with ADHD, 21 children with high-functioning autism (HFA) and 18 control children were tested on the Sustained Attention to Response Task (SART). In a fixed sequence version of the task, children were required to withhold their response to a predictably occurring no-go target (3) in a 1-9 digit sequence; in the random version the sequence was unpredictable. The ADHD group showed clear deficits in response inhibition and sustained attention, through higher errors of commission and omission on both SART versions. The HFA group showed no sustained attention deficits, through a normal number of omission errors on both SART versions. The HFA group showed dissociation in response inhibition performance, as indexed by commission errors. On the Fixed SART, a normal number of errors was made, however when the stimuli were randomised, the HFA group made as many commission errors as the ADHD group. Greater slow-frequency variability in response time and a slowing in mean response time by the ADHD group suggested impaired arousal processes. The ADHD group showed greater fast-frequency variability in response time, indicative of impaired top-down control, relative to the HFA and control groups. These data imply involvement of fronto-parietal attentional networks and sub-cortical arousal systems in the pathology of ADHD and prefrontal cortex dysfunction in children with HFA. © 2007 Elsevier Ltd. All rights reserved.
Language eng
DOI 10.1016/j.neuropsychologia.2007.02.019
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30126163

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.