Hepatitis C virus infection in the elderly

Brind, AM, Watson, Jonathan P, James, OFW and Bassendine, MF 1996, Hepatitis C virus infection in the elderly, QJM: an international journal of medicine, vol. 89, no. 4, pp. 291-296, doi: 10.1093/qjmed/89.4.291.

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Title Hepatitis C virus infection in the elderly
Author(s) Brind, AM
Watson, Jonathan PORCID iD for Watson, Jonathan P orcid.org/0000-0002-2953-9806
James, OFW
Bassendine, MF
Journal name QJM: an international journal of medicine
Volume number 89
Issue number 4
Start page 291
End page 296
Total pages 6
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 1996-04
ISSN 0033-5622
Keyword(s) hepatitis C virus (HCV)
hemodialysis
edema
abdominal pain
chronic
Summary We studied hepatitis C virus (HCV)-related disease in older people because the treatment rationale for younger asymptomatic patients is based on the long-term prognosis of infection. Of the HCV-antibody-positive patients seen at Freeman Hospital 1990-1994, 25 were > 65 years old; 24 were Caucasian and one was Afro-Caribbean. Median age at presentation was 67 years, and five were female. Nine were asymptomatic at presentation, six presented with varices, five with malaise, three with abdominal pain, one with pruritis and one with oedema. Risk factors identified were: transfusion (7), haemodialysis (1), health care worker (dentist) (1), and tattoos (2). There was no recognized risk factor for infection in 14, but five of these had done military service in areas of high HCV prevalence. Liver biopsy in 20 showed chronic hepatitis in two, cirrhosis in 12, and cirrhosis and hepatocellular carcinoma in six. Three additional patients also developed hepatocellular carcinoma. HCV genotyping was done in 19 and all were type 1 (1a, 4; 1b, 14; 1 untypable, 1). Eleven died, at median age 71 years (range 65-94 years), five of HCV liver-related deaths and two from HCV-associated non-hepatic disorders (non-Hodgkin's lymphoma and fibrosing alveolitis).
Language eng
DOI 10.1093/qjmed/89.4.291
Indigenous content off
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1996, Oxford University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30127988

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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