The role of exercise as a non-pharmacological therapeutic approach for amyotrophic lateral sclerosis: beneficial or detrimental?

Tsitkanou, Stavroula, Gatta, Paul Della, Foletta, Victoria and Russell, Aaron 2019, The role of exercise as a non-pharmacological therapeutic approach for amyotrophic lateral sclerosis: beneficial or detrimental?, Frontiers in neurology, vol. 10, pp. 1-14, doi: 10.3389/fneur.2019.00783.

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Title The role of exercise as a non-pharmacological therapeutic approach for amyotrophic lateral sclerosis: beneficial or detrimental?
Author(s) Tsitkanou, Stavroula
Gatta, Paul DellaORCID iD for Gatta, Paul Della orcid.org/0000-0003-2231-8370
Foletta, VictoriaORCID iD for Foletta, Victoria orcid.org/0000-0002-5209-6134
Russell, AaronORCID iD for Russell, Aaron orcid.org/0000-0002-7323-9501
Journal name Frontiers in neurology
Volume number 10
Article ID 783
Start page 1
End page 14
Total pages 14
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2019-07
ISSN 1664-2295
Keyword(s) Amyotrophic lateral sclerosis/ALS
Motor neuron disease
Exercise
Endurance training
Resistance training
SOD1G93A mice
ALS patients
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Summary The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, involves the rapid deterioration of motor neurons resulting in severe muscle atrophy and respiratory insufficiency. It is considered a “multisystemic” disease with many potential mechanisms responsible for its pathology. Currently, there is no cure for ALS. Exercise training is suggested as a potential approach to reduce ALS pathology, but its beneficial role remains controversial. This review provides an overview of the effects of exercise training in ALS-affected mice and patients. It will compare the intensity, duration, and type of exercise on the health of SOD1G93A mice, a mouse model of familial ALS, and review clinical studies involving ALS patients undergoing both endurance and resistance training. In summary, mild-to-moderate swimming-based endurance training appears the most advantageous mode of exercise in SOD1G93A mice, improving animal survival, and delaying the onset and progression of disease. Furthermore, clinical studies show that both endurance and resistance training have an advantageous impact on the quality of life of ALS patients without extending life expectancy. However, small sample sizes, non-representative control populations, heterogeneous disease stage of patients, and the presence of confounders often exist in the exercise studies conducted with ALS patients. This raises concerns about the interpretation of these findings and, therefore, these results should be considered with caution. While promising, more pre-clinical and clinical studies with improved experimental design and fewer limitations are still necessary to confirm the impact of exercise training on the health of ALS patients.
Language eng
DOI 10.3389/fneur.2019.00783
Indigenous content off
Field of Research 1109 Neurosciences
1103 Clinical Sciences
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Tsitkanou, Della Gatta, Foletta and Russell
Persistent URL http://hdl.handle.net/10536/DRO/DU:30128230

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