Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Dascalu, Julian, Liu, Mengjiao, Lycett, Kate, Grobler, Anneke C., He, Mingguang, Burgner, David P., Wong, Tien Yin and Wake, Melissa 2019, Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents, BMJ open, vol. 9, no. Sup 3, pp. 44-52, doi: 10.1136/bmjopen-2018-022399.

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Title Retinal microvasculature: population epidemiology and concordance in Australian children aged 11-12 years and their parents
Author(s) Dascalu, Julian
Liu, Mengjiao
Lycett, KateORCID iD for Lycett, Kate
Grobler, Anneke C.
He, Mingguang
Burgner, David P.
Wong, Tien Yin
Wake, Melissa
Journal name BMJ open
Volume number 9
Issue number Sup 3
Start page 44
End page 52
Total pages 9
Publisher BMJ Publishing
Place of publication London, Eng.
Publication date 2019
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
retinal vessel calibre
retinal vessels
reference values
inheritance patterns
correlation studies
epidemiologic studies
cross-sectional studies
Summary © 2019 BMJ. All rights reserved. Objectives To describe distributions and concordance of retinal microvasculature measurements in a population-based sample of Australian parent-child dyads at child age 11-12 years. Design Cross-sectional Child Health CheckPoint study, between waves 6 and 7 of the national population-based Longitudinal Study of Australian Children (LSAC). Setting Assessment centres in seven Australian cities, February 2015-March 2016. Participants Of the 1874 participating families, 1288 children (51% girls) and 1264 parents (87% mothers, mean age 43.7) were analysed. Diabetic participants and non-biological pairs were excluded from concordance analyses. Outcome measures Retinal photographs were taken by non-mydriatic fundus camera. Trained graders scored vascular calibre using semi-automated software, yielding estimates of central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) and arteriolar-venular ratio (AVR). Pearson's correlation coefficients and multivariable linear regression models assessed parent-child concordance. Survey weights and methods accounted for LSAC's complex sampling, stratification and clustering within postcodes. Results Mean (SD) of CRAE and CRVE were larger in children (159.5 (11.8) and 231.1 (16.5) μm, respectively) than parents (151.5 (14.0) and 220.6 (19.0) μm), yielding similar AVR (children 0.69 (0.05), parents 0.69 (0.06)). Correlation coefficients for parent-child pairs were 0.22 (95% CI 0.16 to 0.27) for CRAE, 0.23 (95% CI 0.17 to 0.28) for CRVE and 0.18 (95% CI 0.13 to 0.24) for AVR. Mother-child and father-child values were similar (0.20 and 0.32 for CRAE, 0.22 and 0.29 for CRVE, respectively). Relationships attenuated slightly on adjustment for age, sex, blood pressure, diabetes and body mass index. Percentiles and concordance are presented for the whole sample and by sex. Conclusions Arteriolar and venular calibre were similar to previously documented measures in midlife adult and late childhood populations. Population parent-child concordance values align with moderate polygenic heritability reported in smaller studies.
Language eng
DOI 10.1136/bmjopen-2018-022399
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
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