Vascular function and stiffness: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Kahn, Freya K., Wake, Melissa, Lycett, Kate, Clifford, Susan, Burgner, David P., Goldsmith, Greta, Grobler, Anneke C., Lange, Katherine and Cheung, Michael 2019, Vascular function and stiffness: population epidemiology and concordance in Australian children aged 11-12 years and their parents, BMJ open, vol. 9, pp. 34-43, doi: 10.1136/bmjopen-2017-020896.

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Title Vascular function and stiffness: population epidemiology and concordance in Australian children aged 11-12 years and their parents
Author(s) Kahn, Freya K.
Wake, Melissa
Lycett, KateORCID iD for Lycett, Kate
Clifford, Susan
Burgner, David P.
Goldsmith, Greta
Grobler, Anneke C.
Lange, Katherine
Cheung, Michael
Journal name BMJ open
Volume number 9
Start page 34
End page 43
Total pages 34
Publisher BMJ Publishing
Place of publication London, Eng.
Publication date 2019
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
blood pressure
vascular stiffness
reference values
inheritance patterns
epidemiologic studies
Summary © 2019 Author(s). Objectives To describe the epidemiology and parent-child concordance of vascular function in a population-based sample of Australian parent-child dyads at child age 11-12 years. Design Cross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC). Setting Assessment centres in seven major Australian cities and eight regional towns or home visits, February 2015-March 2016. Participants Of all participating CheckPoint families (n=1874), 1840 children (49% girls) and 1802 parents (88% mothers) provided vascular function data. Survey weights and methods were applied to account for LSAC's complex sample design and clustering within postcodes and strata. Outcome measures The SphygmoCor XCEL assessed vascular function, generating estimates of brachial and central systolic blood pressure and diastolic blood pressure, central pulse pressure, augmentation index and carotid-femoral pulse wave velocity. Pearson's correlation coefficients and multivariable linear regression models estimated parent-child concordance. Results Hypertension was present in 3.9% of children and 9.0% of parents. Mean child and parent values for augmentation index were 4.5% (SD 11.6) and 21.3% (SD 12.3), respectively, and those for carotid-femoral pulse wave velocity were 4.48 m/s (SD 0.59) and 6.85 m/s (SD 1.14), respectively. Parent-child correlation for brachial systolic blood pressure was 0.20 (95% CI 0.15 to 0.24), brachial diastolic blood pressure 0.21 (95% CI 0.16 to 0.26), central systolic blood pressure 0.21 (95% CI 0.16 to 0.25), central diastolic blood pressure 0.21 (95% CI0.17 to 0.26), central pulse pressure 0.19 (95% CI 0.14 to 0.24), augmentation index 0.28 (95% CI 0.23 to 0.32) and pulse wave velocity 0.22 (95% CI 0.18 to 0.27). Conclusions We report Australian values for traditional and more novel vascular function markers, providing a reference for future population studies. Cross-generational concordance in multiple vascular function markers is already established by age 11-12 years, with mechanisms of heritability remaining to be explored.
Language eng
DOI 10.1136/bmjopen-2017-020896
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
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