PQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Vlok, Jennifer, Simm, Peter J, Lycett, Kate, Clifford, Susan A, Grobler, Anneke C, Lange, Katherine, Ismail, Najmi, Osborn, William and Wake, Melissa 2019, PQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents, BMJ open, vol. 9, no. Suppl 3, pp. 63-74, doi: 10.1136/bmjopen-2018-022400.

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Title PQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents
Author(s) Vlok, Jennifer
Simm, Peter J
Lycett, KateORCID iD for Lycett, Kate orcid.org/0000-0002-8988-4038
Clifford, Susan A
Grobler, Anneke C
Lange, Katherine
Ismail, Najmi
Osborn, William
Wake, Melissa
Journal name BMJ open
Volume number 9
Issue number Suppl 3
Start page 63
End page 74
Total pages 12
Publisher BMJ Publishing Group
Place of publication London, Eng.
Publication date 2019
ISSN 2044-6055
Keyword(s) pQCT bone
Australian children
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
bone health
Peripheral Quantitative Computer Tomography (pqct)
reference values
children patterns
epidemiologic studies
Summary Objectives To describe the epidemiology and concordance of bone health in a population-based sample of Australian parent-child dyads at child age 11-12 years. Design Population-based cross-sectional study (the Child Health CheckPoint) nested between waves 6 and 7 of the Longitudinal Study of Australian Children (LSAC). Setting Assessment centres in seven cities around Australia, February 2015-March 2016. Participants: Of all participating CheckPoint families (n=1874), bone data were available for 1222 dyads (1271 children, 50% girls; 1250 parents, 86% mothers). Outcome measures Peripheral quantitative CT (pQCT) of the non-dominant leg scanned at the 4% (distal) and 66% (mid-calf) tibial sites. Stratec XCT 2000 software generated estimates of bone density, geometry and polar stress-strain index. Parent-child concordance were assessed using Pearson's correlation coefficients and multivariable linear regression models. Percentiles were determined using survey weights. Survey weights and methods accounted for LSAC's complex sampling, stratification and clustering within postcodes. Results Concordances were greater for the geometric pQCT parameters (periosteal circumference 0.38, 95% CI 0.33 to 0.43; endosteal circumference 0.42, 95% CI 0.37 to 0.47; total cross-sectional area 0.37, 95% CI 0.32 to 0.42) than density (cortical density 0.25, 95% CI 0.19 to 0.30). Mother-child and father-child values were similar. Relationships attenuated only slightly on adjustment for age, sex and body mass index. Percentiles and concordance are presented for the whole sample and by sex. Conclusions There is strong parent-child concordance in bone geometry and, to a lesser extent, density even before the period of peak adolescent bone deposition. This geometrical concordance suggests that future intergenerational bone studies could consider using pQCT rather than the more commonly used dual X-ray absorptiometry (DXA).
Language eng
DOI 10.1136/bmjopen-2018-022400
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Author(s) (or their employer(s))
Persistent URL http://hdl.handle.net/10536/DRO/DU:30128496

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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