Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Nguyen, Minh Thien, Lycett, Kate, Vryer, Regan, Burgner, David P., Ranganathan, Sarath, Grobler, Anneke C., Wake, Melissa and Saffery, Richard 2019, Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents, BMJ open, vol. 9, no. Sup 3, pp. 118-126, doi: 10.1136/bmjopen-2017-020263.

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Title Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents
Author(s) Nguyen, Minh Thien
Lycett, KateORCID iD for Lycett, Kate orcid.org/0000-0002-8988-4038
Vryer, Regan
Burgner, David P.
Ranganathan, Sarath
Grobler, Anneke C.
Wake, Melissa
Saffery, Richard
Journal name BMJ open
Volume number 9
Issue number Sup 3
Start page 118
End page 126
Total pages 9
Publisher BMJ Publishing
Place of publication London, Eng.
Publication date 2019
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
telomeres
reference values
children
ageing
inheritance patterns
epidemiological studies
SHORTEST TELOMERE
PATERNAL AGE
METAANALYSIS
HERITABILITY
INFORMATICS
DETERMINANT
INHERITANCE
IMPACT
CELLS
Summary © 2019 Author(s). Objectives To (1) describe the epidemiology of child and adult telomere length, and (2) investigate parent-child telomere length concordance. Design Population-based cross-sectional study within the Longitudinal Study of Australian Children. Setting Assessment centres in seven major Australian cities and eight selected regional towns; February 2015 to March 2016. Participants Of 1874 participating families, telomere data were available for analysis for 1206 children and 1343 parents, of whom 1143 were parent-child pairs. There were 589 boys and 617 girls; 175 fathers and 1168 mothers. Outcome measures Relative telomere length (T/S ratio), calculated by comparing telomeric DNA (T) level with the single copy (S) beta-globin gene in venous blood-derived genomic DNA by quantitative real-time PCR. Results Mean T/S ratio for all children, boys and girls was 1.09 (SD 0.56), 1.05 (SD 0.53) and 1.13 (SD 0.59), respectively. Mean T/S ratio for all parents, fathers and mothers was 0.81 (SD 0.37), 0.82 (SD 0.36) and 0.81 (SD 0.38), respectively. Parent-child T/S ratio concordance was moderate (correlation 0.24). In adjusted regression models, one unit higher parent T/S ratio was associated with 0.36 (estimated linear regression coefficient (β); 95% CI 0.28 to 0.45) higher child T/S ratio. Concordance was higher in the youngest parent-age tertile (β 0.49; 95% CI 0.34 to 0.64) compared with the middle (β 0.35; 95% CI 0.21 to 0.48) and oldest tertile (β 0.26; 95% CI 0.11 to 0.41; p-trend 0.04). Father-child concordance was 0.34 (95% CI 0.18 to 0.48), while mother-child was 0.22 (95% CI 0.17 to 0.28). Conclusions We provide telomere length population values for children aged 11-12 years and their mid-life parents. Relative telomere length was shorter in adults than children, as expected. There was modest evidence of parent-child concordance, which diminished with increasing parent age.
Language eng
DOI 10.1136/bmjopen-2017-020263
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30128497

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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