Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents

Nguyen, Minh Thien, Lycett, Kate, Vryer, Regan, Burgner, David P., Ranganathan, Sarath, Grobler, Anneke C., Wake, Melissa and Saffery, Richard 2019, Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents, BMJ open, vol. 9, no. Sup 3, pp. 118-126, doi: 10.1136/bmjopen-2017-020263.

Attached Files
Name Description MIMEType Size Downloads

Title Telomere length: population epidemiology and concordance in Australian children aged 11-12 years and their parents
Author(s) Nguyen, Minh Thien
Lycett, KateORCID iD for Lycett, Kate
Vryer, Regan
Burgner, David P.
Ranganathan, Sarath
Grobler, Anneke C.
Wake, Melissa
Saffery, Richard
Journal name BMJ open
Volume number 9
Issue number Sup 3
Start page 118
End page 126
Total pages 9
Publisher BMJ Publishing
Place of publication London, Eng.
Publication date 2019
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
reference values
inheritance patterns
epidemiological studies
Summary © 2019 Author(s). Objectives To (1) describe the epidemiology of child and adult telomere length, and (2) investigate parent-child telomere length concordance. Design Population-based cross-sectional study within the Longitudinal Study of Australian Children. Setting Assessment centres in seven major Australian cities and eight selected regional towns; February 2015 to March 2016. Participants Of 1874 participating families, telomere data were available for analysis for 1206 children and 1343 parents, of whom 1143 were parent-child pairs. There were 589 boys and 617 girls; 175 fathers and 1168 mothers. Outcome measures Relative telomere length (T/S ratio), calculated by comparing telomeric DNA (T) level with the single copy (S) beta-globin gene in venous blood-derived genomic DNA by quantitative real-time PCR. Results Mean T/S ratio for all children, boys and girls was 1.09 (SD 0.56), 1.05 (SD 0.53) and 1.13 (SD 0.59), respectively. Mean T/S ratio for all parents, fathers and mothers was 0.81 (SD 0.37), 0.82 (SD 0.36) and 0.81 (SD 0.38), respectively. Parent-child T/S ratio concordance was moderate (correlation 0.24). In adjusted regression models, one unit higher parent T/S ratio was associated with 0.36 (estimated linear regression coefficient (β); 95% CI 0.28 to 0.45) higher child T/S ratio. Concordance was higher in the youngest parent-age tertile (β 0.49; 95% CI 0.34 to 0.64) compared with the middle (β 0.35; 95% CI 0.21 to 0.48) and oldest tertile (β 0.26; 95% CI 0.11 to 0.41; p-trend 0.04). Father-child concordance was 0.34 (95% CI 0.18 to 0.48), while mother-child was 0.22 (95% CI 0.17 to 0.28). Conclusions We provide telomere length population values for children aged 11-12 years and their mid-life parents. Relative telomere length was shorter in adults than children, as expected. There was modest evidence of parent-child concordance, which diminished with increasing parent age.
Language eng
DOI 10.1136/bmjopen-2017-020263
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Checking
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in TR Web of Science
Scopus Citation Count Cited 3 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 8 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 01 Aug 2019, 08:17:51 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact