Longitudinal relationships between cognitive decline and gait slowing: the Tasmanian Study of Cognition and Gait

Callisaya, Michele L, Blizzard, Christopher L, Wood, Amanda G, Thrift, Amanda G, Wardill, Tracey and Srikanth, Velandai K 2014, Longitudinal relationships between cognitive decline and gait slowing: the Tasmanian Study of Cognition and Gait, Journals of gerontology: series A, vol. 70, no. 10, pp. 1226-1232, doi: 10.1093/gerona/glv066.

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Title Longitudinal relationships between cognitive decline and gait slowing: the Tasmanian Study of Cognition and Gait
Author(s) Callisaya, Michele L
Blizzard, Christopher L
Wood, Amanda GORCID iD for Wood, Amanda G orcid.org/0000-0002-1537-6858
Thrift, Amanda G
Wardill, Tracey
Srikanth, Velandai K
Journal name Journals of gerontology: series A
Volume number 70
Issue number 10
Start page 1226
End page 1232
Total pages 7
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2014-10
ISSN 1079-5006
1758-535X
Keyword(s) Gait
Cognition
Executive function
Memory
Aging
Brain
Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Gerontology
Summary Background. Gait slowing and cognitive decline are both common in older people. Although cross-sectionally related, the longitudinal associations between specific cognitive functions and gait speed are less well understood. We aimed to determine whether decline in specific cognitive domains are associated with change in gait speed. Methods. Participants aged 60-85, randomly selected from the electoral roll, were assessed twice over 3 years. Gait speed was obtained using the GAITRite walkway. Raw scores from a cognitive battery were subjected to principal component analyses deriving summary domains of executive function, processing speed, memory, and visuospatial ability. Multivariable linear regression was used to examine the associations between change in each cognitive domain and change in gait speed, adjusting for covariates and stratifying for the presence of baseline cognitive impairment. Results. Mean age at baseline was 71.1 years (SD = 6.7) and 56% (159/284) were men. Mean follow-up was 2.55 (0.47) years. Decline in executive function, but not other cognitive domains (p >. 05), was associated with decline in gait speed, cm/s (β = -3.55, 95% CI = -5.49, -1.61; p <. 001), both in the presence and absence of baseline cognitive impairment. Stronger associations were seen for those with baseline multiple domain cognitive impairment (β = -6.38, 95% CI = -12.49, -0.27) and nonamnestic single-domain cognitive impairment (β = -7.74, 95% CI = -14.76, -0.72). Conclusion. Decline in nonamnestic function (specifically executive function) was associated with decline in gait speed irrespective of the presence of baseline cognitive impairment. Strategies to improve or maintain executive function may prevent gait slowing.
Language eng
DOI 10.1093/gerona/glv066
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30128630

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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