Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex

Sripada, Chandra Sekhar, Phan, K Luan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep J and Wood, Amanda G 2013, Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex, International journal of neuropsychopharmacology, vol. 16, no. 2, pp. 255-260, doi: 10.1017/S1461145712000533.

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Title Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Author(s) Sripada, Chandra Sekhar
Phan, K Luan
Labuschagne, Izelle
Welsh, Robert
Nathan, Pradeep J
Wood, Amanda GORCID iD for Wood, Amanda G orcid.org/0000-0002-1537-6858
Journal name International journal of neuropsychopharmacology
Volume number 16
Issue number 2
Start page 255
End page 260
Total pages 6
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2013-03
ISSN 1461-1457
1469-5111
Keyword(s) Amygdala
fMRI
Medial prefrontal cortex
Oxytocin
Resting-state connectivity
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
Summary The neuropeptide oxytocin (OXT) plays an important role in complex socio-Affective behaviours such as affiliation, attachment, stress and anxiety. Previous studies have focused on the amygdala as an important target of OXT's effects. However, the effects of OXT on connectivity of the amygdala with cortical regions such as medial frontal cortex, an important mediator of social cognition and emotion regulation, remain unexplored. In a randomized, double-blind, cross-over design, 15 volunteers received intranasal OXT or placebo prior to resting-state functional magnetic resonance imaging. OXT significantly increased connectivity between both amygdalae and rostral medial frontal cortex (rmFC), while having only negligible effects on coupling with other brain regions. These results demonstrate that OXT is a robust and highly selective enhancer of amygdala connectivity with rmFC, a region critical to social cognition and emotion regulation, and add to our understanding of the neural mechanisms by which OXT modulates complex social and cognitive behaviours.
Language eng
DOI 10.1017/S1461145712000533
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, CINP
Persistent URL http://hdl.handle.net/10536/DRO/DU:30128649

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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