Prevalence and management practice of first generation antipsychotics induced side effects among schizophrenic patients at Amanuel Mental Specialized Hospital, central Ethiopia: cross-sectional study

Wubeshet, Yirgalem Shewakena, Mohammed, Oumer Sada and Desse, Tigestu Alemu 2019, Prevalence and management practice of first generation antipsychotics induced side effects among schizophrenic patients at Amanuel Mental Specialized Hospital, central Ethiopia: cross-sectional study, BMC Psychiatry, vol. 19, pp. 1-8, doi: 10.1186/s12888-018-1999-x.

Attached Files
Name Description MIMEType Size Downloads

Title Prevalence and management practice of first generation antipsychotics induced side effects among schizophrenic patients at Amanuel Mental Specialized Hospital, central Ethiopia: cross-sectional study
Author(s) Wubeshet, Yirgalem Shewakena
Mohammed, Oumer Sada
Desse, Tigestu AlemuORCID iD for Desse, Tigestu Alemu orcid.org/0000-0002-6116-0433
Journal name BMC Psychiatry
Volume number 19
Article ID 32
Start page 1
End page 8
Total pages 8
Publisher BMC
Place of publication London, Eng.
Publication date 2019-01-18
ISSN 1471-244X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Psychiatry
First generation antipsychotics
Side effects
Schizophrenia
Ethiopia
First generation antipsychotics, Side effects, Schizophrenia, Ethiopia
Summary Background: First-generation antipsychotics (FGAs) are associated with a range of adverse events which cansignificantly reduce patients’ quality of life and contribute to non-adherence. The aim of this study was to assess theprevalence and management practice of first generation antipsychotics induced side effects among schizophrenicpatients.Methods: The study was conducted at Amanuel Mental Specialized Hospital from March to June, 2017. Data frompatients were collected using a pretested structured questionnaire. Demographics and side effects of antipsychoticswere collected by face to face interview. Clinical characteristics, medications and previous history of adverse drugevents were extracted from medical records using data abstraction format. The data were analyzed using statisticalsoftware for social sciences (SPSS) version 20. Descriptive statistics and chi-square tests were done. Statisticalsignificance was considered at p < 0.05.Results: Out of 356 participants, 300 of them had complete data and were included in the study. The mean age ofparticipants was 33.71 ± 10.2 years. The majority, 195(65.0%), of participants were males. Most of the participants,293(97.7%), developed FGA medication induced side effects. One hundred sixty three (54.3%) participants were treatedwith Trihexyphenidyl for FGAs induced side effects. Dose reduction of antipsychotics was done for 51(17.0%)participants. Most of the participants’ side effects were not managed according to American Psychiatric Associationguideline; 178 (82.4%). The most common types of FGAs induced side effects were cardiovascular side effects 169(56.3%); sedation and CNS side effects 149(49.6%); and extrapyramidal side effects 114(38.0%). There is a significantassociation between occurrence of side effects of FGAs and duration of illness (P = 0.04).Conclusions: The prevalence of first generation antipsychotics induced side effects was high. However, managementpractice of the side effects was minimal.
Language eng
DOI 10.1186/s12888-018-1999-x
Indigenous content off
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30129149

Document type: Journal Article
Collections: Faculty of Health
School of Nursing and Midwifery
Open Access Checking
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 12 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Fri, 23 Aug 2019, 08:22:00 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.