Development of solid dispersion lipid nanoparticles for improving skin delivery

Pham, Duong T. T., Tran, Ha Lien Phuong and Tran, Thao T. D. 2019, Development of solid dispersion lipid nanoparticles for improving skin delivery, Saudi Pharmaceutical Journal, pp. 1-6, doi: 10.1016/j.jsps.2019.08.004.

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Title Development of solid dispersion lipid nanoparticles for improving skin delivery
Author(s) Pham, Duong T. T.
Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong orcid.org/0000-0001-8463-7516
Tran, Thao T. D.
Journal name Saudi Pharmaceutical Journal
Start page 1
End page 6
Total pages 6
Publisher Saudi Pharmaceutical Society
Place of publication Riyadh, Kingdom of Saudi Arabia
Publication date 2019
ISSN 1319-0164
Keyword(s) Solid dispersion
Modified solid lipid nanoparticles
Crystal
Skin delivery
Summary Applications of poorly water-soluble drugs in skin delivery pose several challenges to pharmaceutical formulation. This research originally developed solid lipid nanoparticles (SLNs) packaging a modified core of a solid dispersion (SD) in the lipid matrix to modulate the skin release patterns. Curcumin (CUR) was selected as the poorly water-soluble drug applied in the formulation. The designed system, so-called solid dispersion lipid nanoparticles (SD-SLNs), was fabricated by incorporating a solidifying SD or a non-solidifying SD into the core of the SLNs by ultrasonication. Release studies illustrated an important enhancement in the drug release of the proposed system compared to pure CUR and SLN formulations without the presence of SD as the modified core, which indicated the positive effect of the combined colloidal method of SD and SLNs. The physicochemical properties of the SD-SLN systems were also elucidated using powder X-ray diffraction, Fourier transform infrared spectroscopy, and particle size analysis. The drug was found to change to an amorphous state without any molecular interactions along with a marked particle size reduction. This work demonstrated the strong potential of applying a novel SD-SLN system for the skin delivery of a drug with poor water solubility.
Notes In press
Language eng
DOI 10.1016/j.jsps.2019.08.004
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30129902

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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