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Analysis of carbon-based microelectrodes for neurochemical sensing

Manciu, Felicia S., Oh, Yoonbae, Barath, Abhijeet, Rusheen, Aaron E., Kouzani, Abbas, Hodges, Deidra, Guerrero, Jose, Tomshine, Jonathan, Lee, Kendall H. and Bennet, Kevin E. 2019, Analysis of carbon-based microelectrodes for neurochemical sensing, Materials, vol. 12, no. 19, doi: 10.3390/ma12193186.

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Title Analysis of carbon-based microelectrodes for neurochemical sensing
Author(s) Manciu, Felicia S.
Oh, Yoonbae
Barath, Abhijeet
Rusheen, Aaron E.
Kouzani, AbbasORCID iD for Kouzani, Abbas orcid.org/0000-0002-6292-1214
Hodges, Deidra
Guerrero, Jose
Tomshine, Jonathan
Lee, Kendall H.
Bennet, Kevin E.
Journal name Materials
Volume number 12
Issue number 19
Total pages 13
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-10
ISSN 1996-1944
Keyword(s) boron-doped diamond thin film
carbon fiber
confocal Raman spectroscopy
fast-scan cyclic voltammetry (FSCV)
scanning electron microscopy (SEM)
Summary © 2019 by the authors. The comprehensive microscopic, spectroscopic, and in vitro voltammetric analysis presented in this work, which builds on the well-studied properties of carbon-based materials, facilitates potential ways for improvement of carbon fiber microelectrodes (CFMs) for neuroscience applications. Investigations by both, scanning electron microscopy (SEM) and confocal Raman spectroscopy, confirm a higher degree of structural ordering for the fibers exposed to carbonization temperatures. An evident correlation is also identified between the extent of structural defects observed from SEM and Raman results with the CFM electrochemical performance for dopamine detection. To improve CFM physico-chemical surface stability and increase its mechanical resistance to the induced compressive stress during anticipated in vivo tissue penetration, successful coating of the carbon fiber with boron-doped diamond (BDD) is also performed and microspectroscopically analyzed here. The absence of spectral shifts of the diamond Raman vibrational signature verifies that the growth of an unstrained BDD thin film was achieved. Although more work needs to be done to identify optimal parameter values for improved BDD deposition, this study serves as a demonstration of foundational technology for the development of more sensitive electrochemical sensors, that may have been impractical previously for clinical applications, due to limitations in either safety or performance.
Language eng
DOI 10.3390/ma12193186
Indigenous content off
Field of Research 03 Chemical Sciences
09 Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30130687

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.