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Patient perspectives on molecular tumor profiling: "why wouldn't you?"

Best, Megan C., Bartley, Nicole, Jacobs, Chris, Juraskova, Ilona, Goldstein, David, Newson, Ainsley J., Savard, Jacqueline, Meiser, Bettina, Ballinger, Mandy, Napier, Christine, Thomas, David, Biesecker, Barbara, Butow, Phyllis and Members of the PiGeOn Project 2019, Patient perspectives on molecular tumor profiling: "why wouldn't you?", BMC cancer, vol. 19, no. 1, doi: 10.1186/s12885-019-5920-x.

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Title Patient perspectives on molecular tumor profiling: "why wouldn't you?"
Author(s) Best, Megan C.
Bartley, Nicole
Jacobs, Chris
Juraskova, Ilona
Goldstein, David
Newson, Ainsley J.
Savard, JacquelineORCID iD for Savard, Jacqueline orcid.org/0000-0002-7965-6103
Meiser, Bettina
Ballinger, Mandy
Napier, Christine
Thomas, David
Biesecker, Barbara
Butow, Phyllis
Members of the PiGeOn Project
Journal name BMC cancer
Volume number 19
Issue number 1
Total pages 9
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2019-07-31
ISSN 1471-2407
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Oncology
Cancer
Qualitative
Molecular tumor profiling
Genomic
Patient attitudes
Psychosocial
Interviews
Motivation
FAMILY COMMUNICATION
CANCER-RISK
DISCUSSING PROGNOSIS
META-SYNTHESIS
BREAST-CANCER
ATTITUDES
LIFE
DNA
Members of the PiGeOn Project
Summary © 2019 The Author(s). Aim: This study explored the attitudes of patients with advanced cancer towards MTP and return of results, prior to undergoing genomic testing within a research program. Methods: Participants were recruited as part of the longitudinal PiGeOn (Psychosocial Issues in Genomics in Oncology) study involving patients with advanced/metastatic solid cancer who had exhausted therapeutic options and who were offered MTP in order to identify cognate therapies. Twenty patients, selected by purposive sampling, were interviewed around the time they gave consent to MTP. Interviews were audio recorded, transcribed and analysed using thematic analysis. Themes identified in the transcripts were cross-validated via qualitative responses to the PiGeOn study survey (n = 569; 63%). Results: All interviewed participants gave consent to MTP without reservation. Three themes were identified and further supported via the survey responses: (1) Obvious agreement to participate, primarily because of desire for new treatments and altruism. (2) The black box - while participant knowledge of genomics was generally poor, faith in their oncologists and the scientific process encouraged them to proceed with testing; and (3) Survival is the priority - receiving treatment to prolong life was the priority for all participants, and other issues such as identification of a germline variant were generally seen as ancillary. Conclusion: Having advanced cancer seemed to abrogate any potential concerns about MTP. Participants valued the research for varied reasons, but this was secondary to their priority to survive. While no negative attitudes toward MTP emerged, limitations in understanding of genomics were evident.
Language eng
DOI 10.1186/s12885-019-5920-x
Indigenous content off
Field of Research 1112 Oncology and Carcinogenesis
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30130997

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.