Openly accessible

Novel association between plasma matrix metalloproteinase-9 and risk of incident atrial fibrillation in a case-cohort study: the atherosclerosis risk in communities study

Huxley, Rachel R., Lopez, Faye L., MacLehose, Richard F., Eckfeldt, John H., Couper, David, Leiendecker-Foster, Catherine, Hoogeveen, Ron C., Chen, Lin Yee, Soliman, Elsayed Z., Agarwal, Sunil K. and Alonso, Alvaro 2013, Novel association between plasma matrix metalloproteinase-9 and risk of incident atrial fibrillation in a case-cohort study: the atherosclerosis risk in communities study, PLoS One, vol. 8, no. 3, pp. 1-8, doi: 10.1371/journal.pone.0059052.

Attached Files
Name Description MIMEType Size Downloads

Title Novel association between plasma matrix metalloproteinase-9 and risk of incident atrial fibrillation in a case-cohort study: the atherosclerosis risk in communities study
Author(s) Huxley, Rachel R.ORCID iD for Huxley, Rachel R. orcid.org/0000-0002-2705-6616
Lopez, Faye L.
MacLehose, Richard F.
Eckfeldt, John H.
Couper, David
Leiendecker-Foster, Catherine
Hoogeveen, Ron C.
Chen, Lin Yee
Soliman, Elsayed Z.
Agarwal, Sunil K.
Alonso, Alvaro
Journal name PLoS One
Volume number 8
Issue number 3
Start page 1
End page 8
Total pages 8
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2013-03
ISSN 1932-6203
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ABDOMINAL AORTIC-ANEURYSM
CORONARY-ARTERY-DISEASE
MATRIX METALLOPROTEINASES
MYOCARDIAL-INFARCTION
SERUM MATRIX-METALLOPROTEINASE-9
CIRCULATING LEVELS
TISSUE INHIBITORS
HEART-FAILURE
HYPERTENSION
VALIDATION
Summary Background: Previous cross-sectional studies have suggested that biomarkers of extracellular matrix remodelling are associated with atrial fibrillation (AF), but no prospective data have yet been published. Hence, we examine whether plasma matrix metalloproteinases (MMP) and their inhibitors are related to increased risk of incident AF. Methods: We used a case-cohort design in the context of the prospective Atherosclerosis Risk in Communities (ARIC) study. From 13718 eligible men and women free from AF in 1990-92, we selected a stratified random sample of 500 individuals without and 580 with incident AF over a mean follow-up of 11.8 years. Using a weighted proportional hazards regression model, the relationships between MMP-1, MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinase (TIMP)-1, TIMP-2 and C-terminal propeptide of collagen type-I with incident AF were examined after adjusting for confounders. Results: In models adjusted for age, sex and race, all biomarkers were associated with AF, but only the relationship between plasma MMP-9 remained significant in the fully-adjusted model: each one standard deviation increase in MMP-9 was associated with 27% (95% Confidence Interval: 7% to 50%) increase in risk of AF with no evidence of an interaction with race or sex. Individuals with above mean levels of MMP-9 were more likely to be male, white and current smokers. Conclusions: The findings suggest that elevated levels of MMP-9 are independently associated with increased risk of AF. However, given the lack of specificity of MMP-9 to atrial tissue, it remains to be determined whether the observed relationship reflects the impact of atrial fibrosis or more generalized fibrosis on risk of incident AF. 
Language eng
DOI 10.1371/journal.pone.0059052
Indigenous content off
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Huxley et al.
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30131815

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 26 times in TR Web of Science
Scopus Citation Count Cited 24 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 21 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Mon, 18 Nov 2019, 13:42:48 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.