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The epidemiologic evidence and potential biological mechanisms for a protective effect of dietary fiber on the risk of colorectal cancer

Huxley, Rachel R., Woodward, Mark and Clifton, Peter 2013, The epidemiologic evidence and potential biological mechanisms for a protective effect of dietary fiber on the risk of colorectal cancer, Current nutrition reports, vol. 2, pp. 63-70, doi: 10.1007/s13668-012-0030-2.

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Title The epidemiologic evidence and potential biological mechanisms for a protective effect of dietary fiber on the risk of colorectal cancer
Author(s) Huxley, Rachel R.ORCID iD for Huxley, Rachel R. orcid.org/0000-0002-2705-6616
Woodward, Mark
Clifton, Peter
Journal name Current nutrition reports
Volume number 2
Start page 63
End page 70
Total pages 8
Publisher Springer
Place of publication New York, N.Y.
Publication date 2013-03
ISSN 2161-3311
Keyword(s) Epidemiology
Dietary fiber
Colorectal cancer
Biological mechanisms
Summary Cancers of the colon and rectum represent a significant cause of morbidity and mortality worldwide with the burden especially high in North America, Europe, and in some parts of Asia. More than half of the disease burden has been attributed to an inappropriate diet and lifestyle. Low intakes of dietary fiber are considered to be a risk factor for colorectal cancer, although the epidemiological evidence until now has been conflicting in part due to the difficulties in reliably examining the relationships between components of the diet and disease outcomes due to bias, confounding, and measurement error. Results from recently published, large, prospective, cohort studies and from a meta-analysis of the evidence provide "convincing" evidence of an independent dose-response relationship between total dietary fiber intake and increasing risk of colorectal cancer. The anticarcinogenic properties of fiber on cancers of the colon and rectum, however, have still to be elucidated.
Language eng
DOI 10.1007/s13668-012-0030-2
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Springer Science+Business Media New York
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30131817

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
Open Access Collection
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