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Cumulative exposure to ideal cardiovascular health and incident diabetes in a Chinese population: the Kailuan study

Liu, Xiaoxue, Cui, Liufu, Wang, Anxin, Wang, Xizhu, Song, Qiaofeng, Li, Shanshan, Shi, Jihong, Zhao, Xiaohong, Chen, Shuohua, Du, Xin, Ji, Chunpeng, Huxley, Rachel, Guo, Yuming and Wu, Shouling 2016, Cumulative exposure to ideal cardiovascular health and incident diabetes in a Chinese population: the Kailuan study, Journal of the American heart association, vol. 5, no. 9, doi: 10.1161/JAHA.116.004132.

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Title Cumulative exposure to ideal cardiovascular health and incident diabetes in a Chinese population: the Kailuan study
Author(s) Liu, Xiaoxue
Cui, Liufu
Wang, Anxin
Wang, Xizhu
Song, Qiaofeng
Li, Shanshan
Shi, Jihong
Zhao, Xiaohong
Chen, Shuohua
Du, Xin
Ji, Chunpeng
Huxley, RachelORCID iD for Huxley, Rachel orcid.org/0000-0002-2705-6616
Guo, Yuming
Wu, Shouling
Journal name Journal of the American heart association
Volume number 5
Issue number 9
Total pages 20
Publisher Wiley-Blackwell Publishing
Place of publication Hoboken, N. J.
Publication date 2016-08-29
ISSN 2047-9980
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
cardiovascular disease risk factors
cumulative exposure
diabetes mellitus
epidemiology
health status
ideal cardiovascular health
LIFE-STYLE INTERVENTION
IMPAIRED GLUCOSE-TOLERANCE
RESTING HEART-RATE
INSULIN-RESISTANCE
OXIDATIVE STRESS
FOLLOW-UP
RISK
PREVALENCE
OBESITY
REDUCTION
Summary © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. Background: It is unclear whether ideal cardiovascular health (CVH), and particularly cumulative exposure to ideal CVH (cumCVH), is associated with incident diabetes. We aimed to fill this research gap. Methods and Results: The Kailuan Study is a prospective cohort of 101 510 adults aged 18 to 98 years recruited in 2006-2007 and who were subsequently followed up at 2- (Exam 2), 4- (Exam 3), and 6 (Exam 4)-year intervals after baseline. The main analysis is restricted to those individuals with complete follow-up at all 4 examinations and who had no history of diabetes until Exam 3. Cumulative exposure to ideal CVH (cumCVH) was calculated as the summed CVH score for each examination multiplied by the time between the 2 examinations (score×year). Logistic regression models were used to assess the association between cumCVH and incident diabetes. In fully adjusted models, compared with the lowest quintile of cumCVH, individuals in the highest quintile had ~68% (95% confidence interval [CI] 60-75) lower risk for incident diabetes (compared with 61% [95% CI 52-69] lower risk when using baseline CVH). Every additional year lived with a 1-unit increase in ideal CVH was associated with a 24% (95% CI 21-28) reduction in incident diabetes. Conclusions: Ideal CVH is associated with a reduced incidence of diabetes, but the association is likely to be underestimated if baseline measures of CVH exposure are used. Measures of cumulative exposure to ideal CVH are more likely to reflect lifetime risk of diabetes and possibly other health outcomes. Clinical Trial Registration: URL: https://www.chictr.org. Unique identifier: ChiCTRTNC-11001489.
Language eng
DOI 10.1161/JAHA.116.004132
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30131909

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.