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The harms of smoking and benefits of smoking cessation in women compared with men with type 2 diabetes: an observational analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial

Blomster, Juuso I., Woodward, Mark, Zoungas, Sophia, Hillis, Graham S., Harrap, Stephen, Neal, Bruce, Poulter, Neil, Mancia, Giuseppe, Chalmers, John and Huxley, Rachel 2016, The harms of smoking and benefits of smoking cessation in women compared with men with type 2 diabetes: an observational analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, BMJ open, vol. 6, no. 1, doi: 10.1136/bmjopen-2015-009668.

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Title The harms of smoking and benefits of smoking cessation in women compared with men with type 2 diabetes: an observational analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial
Author(s) Blomster, Juuso I.
Woodward, Mark
Zoungas, Sophia
Hillis, Graham S.
Harrap, Stephen
Neal, Bruce
Poulter, Neil
Mancia, Giuseppe
Chalmers, John
Huxley, RachelORCID iD for Huxley, Rachel orcid.org/0000-0002-2705-6616
Journal name BMJ open
Volume number 6
Issue number 1
Total pages 7
Publisher BMJ Publishing
Place of publication London, Eng.
Publication date 2016
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
CORONARY-HEART-DISEASE
CIGARETTE-SMOKING
RISK-FACTOR
EXCESS RISK
METAANALYSIS
INDIVIDUALS
MORTALITY
MELLITUS
OUTCOMES
COHORTS
EPIDEMIOLOGY
PUBLIC HEALTH
Summary Objectives: In general populations, the adverse effects of smoking on coronary risk have been demonstrated to be greater in women than in men; whether this is true for individuals with diabetes is unclear. Design: Cohort study. Setting: 20 countries worldwide participating in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial. Participants: 11 140 patients with type 2 diabetes aged ≥55 years and in cardiovascular risk at the time of randomisation. Primary and secondary outcome measures: Major cardiovascular events (death from cardiovascular disease, non-fatal stroke or non-fatal myocardial infarction (MI)), all cardiovascular events (major cardiovascular event or peripheral arterial disease or transient ischaemic attack), and all-cause mortality. Secondary outcome measures were major coronary events (fatal and non-fatal MI), major cerebrovascular events (fatal and non-fatal stroke), nephropathy (new or worsening renal disease), and all cancer. Results: At baseline, 6466 (56% women) participants were never-smokers, 1550 (28% women) were daily smokers and 3124 (21% women) were former smokers. Median follow-up time was 5 years. In Cox regression models after multiple adjustments, compared with never smoking, daily smoking was associated with increased risk of all primary and secondary outcomes with the exception of major cerebrovascular disease. Only for major coronary events was there any evidence of a stronger effect in women than in men (ratio of the adjusted HRs women:men; 1.64 (0.83 to 3.26) p=0.08).
Language eng
DOI 10.1136/bmjopen-2015-009668
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30131911

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.