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The regulation of mitochondrial metabolism by the Bcl-2 family of pro-survival proteins: new therapeutic opportunities for targeting cancer cells

Guthridge, Mark, Brown, Melissa and Wei, Andrew H. 2013, The regulation of mitochondrial metabolism by the Bcl-2 family of pro-survival proteins: new therapeutic opportunities for targeting cancer cells, Journal of hematology & thromboembolic diseases, vol. 1, no. 4, doi: 10.4172/2329-8790.1000121.

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Title The regulation of mitochondrial metabolism by the Bcl-2 family of pro-survival proteins: new therapeutic opportunities for targeting cancer cells
Author(s) Guthridge, MarkORCID iD for Guthridge, Mark orcid.org/0000-0002-0536-3471
Brown, Melissa
Wei, Andrew H.
Journal name Journal of hematology & thromboembolic diseases
Volume number 1
Issue number 4
Article ID 1000121
Total pages 3
Publisher Longdom Group
Place of publication Hyderabad, India
Publication date 2013
ISSN 2329-8790
Summary Since the identification of the first tumor oncogenesin the 1970s, advances in our understanding of the molecular basis for cellular transformation have continued at a breathtaking rate. Yet compared to other classical hallmarks of cancer such as evading apoptosis, self-sufficiency in growth signals, insensitivity to anti-growth signals and limitless replicative potential, the mechanisms by which transformed cells undergo metabolic reprogramming leading to rampant glycolysis (termed the “Warburg effect”) remain poorly defined. Several very recent studies have revealed that, in addition to their well-established roles in regulating intrinsic apoptosis programs, the Bcl-2 family of pro-survival proteins are also important regulators of mitochondrial respiration and energy generation in cancers such as Acute Myeloid Leukemia (AML). This article discusses some recent advances in our understanding of how the Bcl-2 family of proteins regulate cellular metabolism and how exploiting metabolic vulnerabilities in transformed cells by direct targeting of the Bcl-2 proteins may provide new clinical avenues for the treatment of cancer.
Language eng
DOI 10.4172/2329-8790.1000121
Indigenous content off
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Wei AH, et al.
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30132278

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.