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Pulmonary delivery of an ultra-fine oxytocin dry powder formulation: potential for treatment of postpartum haemorrhage in developing countries

Prankerd, Richard J., Nguyen, Tri-Hung, Ibrahim, Jibriil P., Bischof, Robert J., Nassta, Gemma C., Olerile, Livesey D., Russell, Adrian S., Meiser, Felix, Parkington, Helena C., Coleman, Harold A., Morton, David A.V. and McIntosh, Michelle P. 2013, Pulmonary delivery of an ultra-fine oxytocin dry powder formulation: potential for treatment of postpartum haemorrhage in developing countries, PloS One, vol. 8, no. 12, pp. 1-9, doi: 10.1371/journal.pone.0082965.

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Title Pulmonary delivery of an ultra-fine oxytocin dry powder formulation: potential for treatment of postpartum haemorrhage in developing countries
Author(s) Prankerd, Richard J.
Nguyen, Tri-Hung
Ibrahim, Jibriil P.
Bischof, Robert J.
Nassta, Gemma C.
Olerile, Livesey D.
Russell, Adrian S.
Meiser, Felix
Parkington, Helena C.
Coleman, Harold A.
Morton, David A.V.ORCID iD for Morton, David A.V. orcid.org/0000-0002-1491-6517
McIntosh, Michelle P.
Journal name PloS One
Volume number 8
Issue number 12
Start page 1
End page 9
Total pages 9
Publisher Public Library of Science
Place of publication e82965
Publication date 2013
ISSN 1932-6203
1932-6203
Summary Oxytocin is recommended by the World Health Organisation as the most effective uterotonic for the prevention and treatment of postpartum haemorrhage. The requirement for parenteral administration by trained healthcare providers and the need for the drug solution to be maintained under cold-chain storage limit the use of oxytocin in the developing world. In this study, a spray-dried ultrafine formulation of oxytocin was developed with an optimal particle size diameter (1-5 μm) to facilitate aerosolised delivery via the lungs. A powder formulation of oxytocin, using mannitol, glycine and leucine as carriers, was prepared with a volume-based median particle diameter of 1.9 μm. Oxytocin content in the formulation was assayed using high-performance liquid chromatography-mass spectroscopy and was found to be unchanged after spray-drying. Ex vivo contractility studies utilising human and ovine uterine tissue indicated no difference in the bioactivity of oxytocin before and after spray-drying. Uterine electromyographic (EMG) activity in postpartum ewes following pulmonary (in vivo) administration of oxytocin closely mimicked that observed immediately postpartum (0-12 h following normal vaginal delivery of the lamb). In comparison to the intramuscular injection, pulmonary administration of an oxytocin dry powder formulation to postpartum ewes resulted in generally similar EMG responses, however a more rapid onset of uterine EMG activity was observed following pulmonary administration (129 ± 18 s) than intramuscular injection (275 ± 22 s). This is the first study to demonstrate the potential for oxytocin to elicit uterine activity after systemic absorption as an aerosolised powder from the lungs. Aerosolised oxytocin has the potential to provide a stable and easy to administer delivery system for effective prevention and treatment of postpartum haemorrhage in resource-poor settings in the developing world. © 2013 Prankerd et al.
Language eng
DOI 10.1371/journal.pone.0082965
Indigenous content off
Field of Research MD Multidisciplinary
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Prankerd et al.
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30132630

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Citation counts: TR Web of Science Citation Count  Cited 12 times in TR Web of Science
Scopus Citation Count Cited 13 times in Scopus
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.