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Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)

Wijndaele, Katrien, White, Thomas, Andersen, Lars Bo, Bugge, Anna, Kolle, Elin, Northstone, Kate, Wedderkopp, Niels, Ried-Larsen, Mathias, Kriemler, Susi, Page, Angie S., Puder, Jardena J., Reilly, John J., Sardinha, Luis B., Van Sluijs, Esther M. F., Sharp, Stephen J., Brage, Soren, Ekelund, Ulf, Salmon, Jo-Ann and Timperio, Anna 2019, Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD), International journal of behavioral nutrition and physical activity, vol. 16, pp. 1-10, doi: 10.1186/s12966-019-0858-6.

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Title Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)
Author(s) Wijndaele, Katrien
White, Thomas
Andersen, Lars Bo
Bugge, Anna
Kolle, Elin
Northstone, Kate
Wedderkopp, Niels
Ried-Larsen, Mathias
Kriemler, Susi
Page, Angie S.
Puder, Jardena J.
Reilly, John J.
Sardinha, Luis B.
Van Sluijs, Esther M. F.
Sharp, Stephen J.
Brage, Soren
Ekelund, Ulf
Salmon, Jo-AnnORCID iD for Salmon, Jo-Ann orcid.org/0000-0002-4734-6354
Timperio, AnnaORCID iD for Timperio, Anna orcid.org/0000-0002-8773-5012
Journal name International journal of behavioral nutrition and physical activity
Volume number 16
Article ID 96
Start page 1
End page 10
Total pages 10
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2019
ISSN 1479-5868
Keyword(s) ICAD
ALSPAC
Prolonged sitting
Cardio-metabolic
Iso-temporal
Physical activity
Summary Background: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children. Methods: Cross-sectional data from 14 studies (7 countries) in the International Children's Accelerometry Database (ICAD, 1998-2009) was included. Accelerometry in 19,502 participants aged 3-18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed. Results: Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (- 0.44 (- 0.62; - 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (- 3.07 (- 4.47; - 1.68) cm), systolic blood pressure (- 1.53 (- 2.42; - 0.65) mmHg) and clustered cardio-metabolic risk (- 0.18 (- 0.3; - 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: - 0.81 (- 1.38; - 0.24) mmHg). Conclusions: Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.
Language eng
DOI 10.1186/s12966-019-0858-6
Indigenous content off
Field of Research 11 Medical and Health Sciences
13 Education
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Author(s)
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30132691

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.