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The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: An exploratory study

Cruickshank, Travis M., Thompson, Jennifer A., Domínguez Duque, Juan F., Reyes, Alvaro P., Bynevelt, Mike, Georgiou-Karistianis, Nellie, Barker, Roger A. and Ziman, Mel R. 2015, The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: An exploratory study, Brain and Behavior, vol. 5, no. 2, pp. 1-10, doi: 10.1002/brb3.312.

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Title The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: An exploratory study
Author(s) Cruickshank, Travis M.
Thompson, Jennifer A.
Domínguez Duque, Juan F.ORCID iD for Domínguez Duque, Juan F. orcid.org/0000-0002-6715-1060
Reyes, Alvaro P.
Bynevelt, Mike
Georgiou-Karistianis, Nellie
Barker, Roger A.
Ziman, Mel R.
Journal name Brain and Behavior
Volume number 5
Issue number 2
Article ID e00312
Start page 1
End page 10
Total pages 10
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-02-01
ISSN 2162-3279
Keyword(s) Cognition
executive function
Huntington’s disease
neuropathology
rehabilitation
Science & Technology
Life Sciences & Biomedicine
Behavioral Sciences
Neurosciences
Neurosciences & Neurology
Huntington's disease
VOXEL-BASED MORPHOMETRY
TRANSGENIC MOUSE MODEL
WHITE-MATTER
CONNECTIVITY CHANGES
EXECUTIVE FUNCTIONS
MULTIPLE-SCLEROSIS
TRACK-HD
MEMORY
PREMANIFEST
PLASTICITY
Summary © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. Background: There is a wealth of evidence detailing gray matter degeneration and loss of cognitive function over time in individuals with Huntington's disease (HD). Efforts to attenuate disease-related brain and cognitive changes have been unsuccessful to date. Multidisciplinary rehabilitation, comprising motor and cognitive intervention, has been shown to positively impact on functional capacity, depression, quality of life and some aspects of cognition in individuals with HD. This exploratory study aimed to evaluate, for the first time, whether multidisciplinary rehabilitation can slow further deterioration of disease-related brain changes and related cognitive deficits in individuals with manifest HD. Methods: Fifteen participants who manifest HD undertook a multidisciplinary rehabilitation intervention spanning 9 months. The intervention consisted of once-weekly supervised clinical exercise, thrice-weekly self-directed home based exercise and fortnightly occupational therapy. Participants were assessed using MR imaging and validated cognitive measures at baseline and after 9 months. Results: Participants displayed significantly increased gray matter volume in the right caudate and bilaterally in the dorsolateral prefrontal cortex after 9 months of multidisciplinary rehabilitation. Volumetric increases in gray matter were accompanied by significant improvements in verbal learning and memory (Hopkins Verbal Learning-Test). A significant association was found between gray matter volume increases in the dorsolateral prefrontal cortex and performance on verbal learning and memory. Conclusions: This study provides preliminary evidence that multidisciplinary rehabilitation positively impacts on gray matter changes and cognitive functions relating to verbal learning and memory in individuals with manifest HD. Larger controlled trials are required to confirm these preliminary findings.
Language eng
DOI 10.1002/brb3.312
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30133956

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.