Objectively measured sleep and telomere length in a population-based cohort of children and midlife adults

Nguyen, Minh Thien, Lycett, Kate, Olds, Timothy, Matricciani, Lisa, Vryer, Regan, Ranganathan, Sarath, Burgner, David, Saffery, Richard and Wake, Melissa 2020, Objectively measured sleep and telomere length in a population-based cohort of children and midlife adults, Sleep, vol. 43, no. 1, pp. 1-9, doi: 10.1093/sleep/zsz200.

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Title Objectively measured sleep and telomere length in a population-based cohort of children and midlife adults
Author(s) Nguyen, Minh Thien
Lycett, KateORCID iD for Lycett, Kate orcid.org/0000-0002-8988-4038
Olds, Timothy
Matricciani, Lisa
Vryer, Regan
Ranganathan, Sarath
Burgner, David
Saffery, Richard
Wake, Melissa
Journal name Sleep
Volume number 43
Issue number 1
Article ID zsz200
Start page 1
End page 9
Total pages 9
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2020-01
ISSN 1550-9109
Keyword(s) actigraphy
aging
biomarkers
cell senescence
cellular and molecular biology
epidemiology
pediatrics
telomere length
Summary STUDY OBJECTIVES: Poor sleep patterns in older adults are associated with chromosomal telomere shortening, a marker of cellular senescence. However, studies have relied on self-reported sleep characteristics, with few data for younger individuals. We investigated whether sleep measured via actigraphy was cross-sectionally associated with telomere length in children and midlife adults. METHODS: A population-based sample of 1874 11-12 year olds and midlife adults (mean age 44 years, SD 5.1) had biological and physical assessments at centers across Australia in 2015-2016. Sleep characteristics, including duration, onset, offset, day-to-day variability, and efficiency, were derived from actigraphy. Relative telomere length (T/S ratio) was measured by quantitative polymerase chain reaction on genomic DNA from peripheral blood. Multivariable regression models estimated associations, adjusting for prespecified confounders. RESULTS: Both sleep and telomere data were available for 728 children and 1070 adults. Mean (SD) T/S ratio was 1.09 (0.55) in children and 0.81 (0.38) in adults. T/S ratio was not predicted by sleep duration (β 0.04, 95% confidence interval [CI] -0.02 to 0.09, p = .16, children; β -0.004, 95% CI -0.03 to 0.02, p = .70, adults) or most other sleep metrics. The only exception was a weak association between later sleep timing (the midpoint of sleep onset and offset) and longer telomeres in adults (β 0.03, 95% CI 0.01 to 0.06, p = .01). CONCLUSIONS: Objective sleep characteristics show no convincing associations with telomere length in two largely healthy populations up to at least midlife. Sleep-telomere associations may be a late-life occurrence or may present only with a trigger such as presence of other morbidities.
Language eng
DOI 10.1093/sleep/zsz200
Indigenous content off
Field of Research 119999 Medical and Health Sciences not elsewhere classified
06 Biological Sciences
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30134170

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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