Openly accessible

Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia

Lee, CMY, Woodward, M, Batty, GD, Beiser, AS, Bell, S, Berr, C, Bjertness, E, Chalmers, J, Clarke, R, Dartigues, JF, Davis-Plourde, K, Debette, S, Di Angelantonio, E, Feart, C, Frikke-Schmidt, R, Gregson, J, Haan, MN, Hassing, LB, Hayden, KM, Hoevenaar-Blom, MP, Kaprio, J, Kivimaki, M, Lappas, G, Larson, EB, LeBlanc, ES, Lee, A, Lui, LY, Moll van Charante, EP, Ninomiya, T, Nordestgaard, LT, Ohara, T, Ohkuma, T, Palviainen, T, Peres, K, Peters, R, Qizilbash, N, Richard, E, Rosengren, A, Seshadri, S, Shipley, M, Singh-Manoux, A, Strand, BH, van Gool, WA, Vuoksimaa, E, Yaffe, K and Huxley, RR 2020, Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia, Obesity Reviews, vol. 21, no. 4, pp. 1-14, doi: 10.1111/obr.12989.

Attached Files
Name Description MIMEType Size Downloads
huxley-associationofanthropometry-2020.pdf Published version application/pdf 1.63MB 6

Title Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
Author(s) Lee, CMY
Woodward, M
Batty, GD
Beiser, AS
Bell, S
Berr, C
Bjertness, E
Chalmers, J
Clarke, R
Dartigues, JF
Davis-Plourde, K
Debette, S
Di Angelantonio, E
Feart, C
Frikke-Schmidt, R
Gregson, J
Haan, MN
Hassing, LB
Hayden, KM
Hoevenaar-Blom, MP
Kaprio, J
Kivimaki, M
Lappas, G
Larson, EB
LeBlanc, ES
Lee, A
Lui, LY
Moll van Charante, EP
Ninomiya, T
Nordestgaard, LT
Ohara, T
Ohkuma, T
Palviainen, T
Peres, K
Peters, R
Qizilbash, N
Richard, E
Rosengren, A
Seshadri, S
Shipley, M
Singh-Manoux, A
Strand, BH
van Gool, WA
Vuoksimaa, E
Yaffe, K
Huxley, RRORCID iD for Huxley, RR orcid.org/0000-0002-2705-6616
Journal name Obesity Reviews
Volume number 21
Issue number 4
Article ID e12989
Start page 1
End page 14
Total pages 14
Publisher Wiley
Place of publication Hoboken, NJ
Publication date 2020-04
ISSN 1467-7881
1467-789X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
BODY-MASS INDEX
FOLLOW-UP
ALZHEIMERS-DISEASE
VASCULAR DEMENTIA
FUTURE RISK
LATE-LIFE
MIDLIFE
MORTALITY
OBESITY
POPULATION
Summary Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta‐analysis. Compared with body mass index–defined lower‐normal weight (18.5‐22.4 kg/m2), the risk of all‐cause dementia was higher among underweight individuals but lower among those with upper‐normal (22.5‐24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all‐cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non‐linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
Language eng
DOI 10.1111/obr.12989
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30134284

Document type: Journal Article
Collections: Faculty of Health
PVC's Office - Health
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in TR Web of Science
Scopus Citation Count Cited 4 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 30 Abstract Views, 6 File Downloads  -  Detailed Statistics
Created: Fri, 31 Jan 2020, 13:42:04 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.