Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?

Guthridge, Mark A and Lopez, AF 2007, Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?, BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 35, no. 2, pp. 250-252, doi: 10.1042/BST0350250.


Title Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?
Author(s) Guthridge, Mark AORCID iD for Guthridge, Mark A orcid.org/0000-0002-0536-3471
Lopez, AF
Journal name BIOCHEMICAL SOCIETY TRANSACTIONS
Volume number 35
Issue number 2
Start page 250
End page 252
Total pages 3
Publisher PORTLAND PRESS LTD
Place of publication Bath, ENGLAND
Publication date 2007-04-01
ISSN 0300-5127
1470-8752
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
14-3-3 protein
cytokine
growth factor
phosphoinositide 3-kinase (PI3K)
phosphorylation
pleiotropy
RECEPTOR
SPECIFICITY
TRANSDUCTION
Summary Cytokines and growth factors exert multiple biological activities through their ability to engage and activate specific receptors displayed on the surface of cells. How these receptors are able to differentially (and sometimes independently) regulate cell survival, proliferation, differentiation and activation to control quite specific and distinct cellular outcomes is unclear. Similarly, how a single growth factor or cytokine receptor can specify alternate cellular responses and control very different cellular fates is also not known. We present a new mechanism by which cytokines and growth factors are able to control these pleiotropic responses.
Language eng
DOI 10.1042/BST0350250
Indigenous content off
Field of Research 0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
HERDC Research category CN.1 Other journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30134408

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