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Bone health in bipolar disorder: a study protocol for a case-control study in Australia

Williams, Lana J, Stuart, Amanda L, Berk, Michael, Brennan-Olsen, Sharon L, Hodge, Jason M., Cowdery, Stephanie, Chandrasekaran, Vinoomika and Pasco, Julie A. 2020, Bone health in bipolar disorder: a study protocol for a case-control study in Australia, BMJ Open, vol. 10, no. 2, pp. 1-6, doi: 10.1136/bmjopen-2019-032821.

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Title Bone health in bipolar disorder: a study protocol for a case-control study in Australia
Author(s) Williams, Lana JORCID iD for Williams, Lana J orcid.org/0000-0002-1377-1272
Stuart, Amanda LORCID iD for Stuart, Amanda L orcid.org/0000-0001-8770-9511
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Brennan-Olsen, Sharon LORCID iD for Brennan-Olsen, Sharon L orcid.org/0000-0003-3269-5401
Hodge, Jason M.
Cowdery, Stephanie
Chandrasekaran, VinoomikaORCID iD for Chandrasekaran, Vinoomika orcid.org/0000-0002-3910-3248
Pasco, Julie A.ORCID iD for Pasco, Julie A. orcid.org/0000-0002-8968-4714
Journal name BMJ Open
Volume number 10
Issue number 2
Start page 1
End page 6
Total pages 6
Publisher BMJ Open
Place of publication London, Eng.
Publication date 2020-02
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
PHYSICAL-ACTIVITY
RATING-SCALE
DEPRESSION
QUESTIONNAIRE
VALIDATION
RELIABILITY
SEVERITY
VALIDITY
SAMPLE
WOMEN
bipolar disorder
bone mineral density
health
lifestyle
medical conditions
osteoporosis
Summary Little is known about the bone health of adults with bipolar disorder, aside from evidence purporting bone deficits among individuals with other mental illnesses, or those taking medications commonly used in bipolar disorder. In this paper, we present the methodology of a case-control study which aims to examine the role of bipolar disorder as a risk factor for bone fragility. Methods and analysis Men and women with bipolar disorder (∼200 cases) will be recruited and compared with participants with no history of bipolar disorder (∼1500 controls) from the Geelong Osteoporosis Study. Both cases and controls will be drawn from the Barwon Statistical Division, south-eastern Australia. The Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition is the primary diagnostic instrument, and psychiatric symptomatology will be assessed using validated rating scales. Demographic information and detailed lifestyle data and medical history will be collected via comprehensive questionnaires. Participants will undergo dual energy X-ray absorptiometry scans and other clinical measures to determine bone and body composition. Blood samples will be provided after an overnight fast and stored for batch analysis. Ethics and dissemination Ethics approval has been granted from Barwon Health Research Ethics Committee. Participation in the study is voluntary. The study findings will be disseminated via peer-reviewed publications, conference presentations and reports to the funding body.
Language eng
DOI 10.1136/bmjopen-2019-032821
Indigenous content off
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30135587

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.