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Aptamer-guided extracellular vesicle theranostics in oncology

Tran, Phuong H-L, Xiang, Dongxi, Nguyen, Tuong N-G, Tran, Thao T-D, Chen, Qian, Yin, Wang, Zhang, Yumei, Kong, Lingxue, Duan, Andrew, Chen, Kuisheng, Sun, Miomio, Li, Yong, Hou, Yingchun, Zhu, Yimin, Ma, Yongchao, Jiang, Guoqin and Duan, Wei 2020, Aptamer-guided extracellular vesicle theranostics in oncology, Theranostics, vol. 10, no. 9, pp. 3849-3866, doi: 10.7150/thno.39706.

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Title Aptamer-guided extracellular vesicle theranostics in oncology
Author(s) Tran, Phuong H-LORCID iD for Tran, Phuong H-L orcid.org/0000-0001-8463-7516
Xiang, Dongxi
Nguyen, Tuong N-GORCID iD for Nguyen, Tuong N-G orcid.org/0000-0003-1007-273X
Tran, Thao T-D
Chen, Qian
Yin, Wang
Zhang, Yumei
Kong, LingxueORCID iD for Kong, Lingxue orcid.org/0000-0001-6219-3897
Duan, Andrew
Chen, Kuisheng
Sun, Miomio
Li, Yong
Hou, Yingchun
Zhu, Yimin
Ma, Yongchao
Jiang, Guoqin
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Journal name Theranostics
Volume number 10
Issue number 9
Start page 3849
End page 3866
Total pages 18
Publisher Ivyspring International Publisher
Place of publication Sydney, N.S.W.
Publication date 2020
ISSN 1838-7640
Keyword(s) exosomes
aptamers
theranostics
liquid biopsy
targeting
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
PROSTATE-CANCER
DIAGNOSTIC BIOMARKERS
DNA APTAMERS
STEM-CELLS
RNA
EPCAM
MICRORNA
DOXORUBICIN
LIMITATIONS
Summary In the past decade, the study of exosomes, nanosized vesicles (50-150 nm) released into the extracellular space via the fusion of multivesicular bodies with the plasma membrane, has burgeoned with impressive achievements in theranostics applications. These nanosized vesicles have emerged as key players in homeostasis and in the pathogenesis of diseases owing to the variety of the cargos they can carry, the nature of the molecules packaged inside the vesicles, and the robust interactions between exosomes and target cells or tissues. Accordingly, the development of exosome-based liquid biopsy techniques for early disease detection and for monitoring disease progression marks a new era of precision medicine in the 21st century. Moreover, exosomes possess intrinsic properties - a nanosized structure and unique "homing effects" - that make them outstanding drug delivery vehicles. In addition, targeted exosome-based drug delivery systems can be further optimized using active targeting ligands such as nucleic acid aptamers. Indeed, the aptamers themselves can function as therapeutic and/or diagnostic tools based on their attributes of unique target-binding and non-immunogenicity. This review aims to provide readers with a current picture of the research on exosomes and aptamers and their applications in cancer theranostics, highlighting recent advances in their transition from the bench to the clinic.
Language eng
DOI 10.7150/thno.39706
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30135716

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.