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Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Bikbov, B, Purcell, CA, Levey, AS, Smith, M, Abdoli, A, Abebe, M, Adebayo, OM, Afarideh, M, Agarwal, SK, Agudelo-Botero, M, Ahmadian, E, Al-Aly, Z, Alipour, V, Almasi-Hashiani, A, Al-Raddadi, RM, Alvis-Guzman, N, Amini, S, Andrei, T, Andrei, CL, Andualem, Z and Shariful Islam, Sheikh 2020, Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017, The Lancet, vol. 395, no. 10225, pp. 709-733, doi: 10.1016/S0140-6736(20)30045-3.

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Title Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Author(s) Bikbov, B
Purcell, CA
Levey, AS
Smith, M
Abdoli, A
Abebe, M
Adebayo, OM
Afarideh, M
Agarwal, SK
Agudelo-Botero, M
Ahmadian, E
Al-Aly, Z
Alipour, V
Almasi-Hashiani, A
Al-Raddadi, RM
Alvis-Guzman, N
Amini, S
Andrei, T
Andrei, CL
Andualem, Z
Shariful Islam, SheikhORCID iD for Shariful Islam, Sheikh orcid.org/0000-0001-7926-9368
Journal name The Lancet
Volume number 395
Issue number 10225
Start page 709
End page 733
Total pages 25
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2020-02-29
ISSN 0140-6736
1474-547X
Keyword(s) GBD Chronic Kidney Disease Collaboration
Summary Background: Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods: The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings: Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation: Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI. Funding: Bill & Melinda Gates Foundation.
Language eng
DOI 10.1016/S0140-6736(20)30045-3
Indigenous content off
Field of Research 11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30135720

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.