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Mobilizing serum factors and immune cells through exercise to counteract age-related changes in cancer risk

Hwang, Ji Hui, McGovern, Jacqui, Minett, Geoffrey M., Della Gatta, Paul A., Roberts, Llion, Harris, Jonathan M., Thompson, Erik W., Parker, Tony J., Peake, Jonathan M. and Neubauer, Oliver 2020, Mobilizing serum factors and immune cells through exercise to counteract age-related changes in cancer risk, Exercise immunology review, vol. 26, pp. 80-99.

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Title Mobilizing serum factors and immune cells through exercise to counteract age-related changes in cancer risk
Author(s) Hwang, Ji Hui
McGovern, Jacqui
Minett, Geoffrey M.
Della Gatta, Paul A.ORCID iD for Della Gatta, Paul A. orcid.org/0000-0003-2231-8370
Roberts, Llion
Harris, Jonathan M.
Thompson, Erik W.
Parker, Tony J.
Peake, Jonathan M.
Neubauer, Oliver
Journal name Exercise immunology review
Volume number 26
Start page 80
End page 99
Total pages 20
Publisher Human Kinetics
Place of publication Champaign, I.L.
Publication date 2020
ISSN 1077-5552
Keyword(s) ageing
cancer development
cancer growth-inhibitory molecular factors
exercise
immune-regulatory myokines
immuno-surveillance
Summary All rights reserved. An increasing body of evidence suggests that age-related immune changes and chronic inflammation contribute to cancer development. Recognizing that exercise has protective effects against cancer, promotes immune function, and beneficially modulates inflammation with ageing, this review outlines the current evidence indicating an emerging role for exercise immunology in preventing and treating cancer in older adults. A specific focus is on data suggesting that muscle- derived cytokines (myokines) mediate anti-cancer effects through promoting immunosurveillance against tumourigenesis or inhibiting cancer cell viability. Previous studies suggested that the exercise-induced release of myokines and other endocrine factors into the blood increases the capacity of blood serum to inhibit cancer cell growth in vitro. However, little is known about whether this effect is influenced by ageing. Prostate cancer is the second most common cancer in men. We therefore examined the effects of serum collected before and after exercise from healthy young and older men on the metabolic activity of androgen-responsive LNCaP and androgen-unresponsive PC3 prostate cancer cells. Exercise-conditioned serum collected from the young group did not alter cell metabolic activity, whereas post-exercise serum (compared with pre-exercise serum) from the older men inhibited the metabolic activity of LNCaP cancer cells. Serum levels of candidate cancer-inhibitory myokines oncostatin M and osteonectin increased in both age groups following exercise. Serum testosterone increased only in the younger men postexercise, potentially attenuating inhibitory effects of myokines on the LNCaP cell viability. The data from our study and the evidence in this review suggest that mobilizing serum factors and immune cells may be a key mechanism of how exercise counteracts cancer in the older population.
Language eng
Indigenous content off
Field of Research 1106 Human Movement and Sports Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, International Society of Exercise and Immunology
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30135725

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.