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Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis

Bortolasci, Chiara C, Marx, Wolfgang, Walker, Adam J, Hasebe, Kyoko, Kavanagh, Bianca E, Morris, Margaret J, Mohebbi, Mohammadreza, Turner, Alyna, Gray, Laura, Berk, Lesley, Walder, Ken, Berk, Michael and Dean, Olivia M 2020, Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis, BMJ open, vol. 10, no. 3, pp. 1-4, doi: 10.1136/bmjopen-2019-035080.

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Title Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis
Author(s) Bortolasci, Chiara CORCID iD for Bortolasci, Chiara C orcid.org/0000-0002-0794-6363
Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
Walker, Adam JORCID iD for Walker, Adam J orcid.org/0000-0002-5399-1245
Hasebe, Kyoko
Kavanagh, Bianca EORCID iD for Kavanagh, Bianca E orcid.org/0000-0002-1656-2775
Morris, Margaret J
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza orcid.org/0000-0001-9713-7211
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Gray, LauraORCID iD for Gray, Laura orcid.org/0000-0002-7903-5796
Berk, LesleyORCID iD for Berk, Lesley orcid.org/0000-0002-3677-7503
Walder, KenORCID iD for Walder, Ken orcid.org/0000-0002-6758-4763
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Dean, Olivia MORCID iD for Dean, Olivia M orcid.org/0000-0002-2776-3935
Journal name BMJ open
Volume number 10
Issue number 3
Article ID e035080
Start page 1
End page 4
Total pages 4
Publisher BMJ
Place of publication London, Eng.
Publication date 2020
ISSN 2044-6055
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
OXIDATIVE STRESS
INFLAMMATION
PATHOPHYSIOLOGY
SCHIZOPHRENIA
NEUROGENESIS
EFFICACY
DISEASE
neurology
protocols & guidelines
psychiatry
Summary INTRODUCTION: Due to the anti-inflammatory, antioxidant and anti-apoptotic properties of minocycline, clinical trials have evaluated the potential of this drug to treat several psychiatric and neurological disorders, including major depressive disorder, schizophrenia, bipolar disorder, stroke and amyotrophic lateral sclerosis. This protocol proposes a systematic review (and potential meta-analysis) that aims to identify and critically evaluate randomised controlled trials of minocycline for treating psychiatric and neurological disorders. METHODS AND ANALYSIS: PubMed, Embase, Cochrane Central Register of Controlled Clinical Trials, PsycINFO and Cumulative Index to Nursing and Allied Health Literature (CINAHL) will be used to identify randomised controlled trials that used minocycline to treat psychiatric and neurological disorders. Double-blind, randomised, controlled, clinical trials of participants aged 18 years or older and written in English will be included in the review. Data will be extracted by two independent reviewers. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines will be followed and the Cochrane Collaboration's 'Risk of Bias' tool will be used to assess the risk of bias in all studies included in the systematic review. The Grading of Recommendations, Assessment, Development and Evaluation system will be used to access the overall quality of the level of evidence of the studies. If sufficient evidence is identified, a meta-analysis will be conducted using the standardised mean difference approach and reported with 95% CIs. Heterogeneity of evidence will be evaluated using the I2 model. ETHICS AND DISSEMINATION: This systematic review will evaluate only published data; therefore, ethical approval is not required. The systematic review will be published in a peer-reviewed journal and presented at relevant research conferences. 
Language eng
DOI 10.1136/bmjopen-2019-035080
Indigenous content off
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30135780

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.