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Antibodies, nanobodies, or aptamers—which is best for deciphering the proteomes of non-model species?

Dhar, Poshmaal, Samarasinghe, Rasika M. and Shigdar, Sarah 2020, Antibodies, nanobodies, or aptamers—which is best for deciphering the proteomes of non-model species?, International journal of molecular sciences, vol. 21, no. 7, pp. 1-14, doi: 10.3390/ijms21072485.

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Title Antibodies, nanobodies, or aptamers—which is best for deciphering the proteomes of non-model species?
Author(s) Dhar, Poshmaal
Samarasinghe, Rasika M.ORCID iD for Samarasinghe, Rasika M. orcid.org/0000-0002-3669-0985
Shigdar, SarahORCID iD for Shigdar, Sarah orcid.org/0000-0001-8084-8447
Journal name International journal of molecular sciences
Volume number 21
Issue number 7
Start page 1
End page 14
Total pages 14
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2020
ISSN 1661-6596
1422-0067
Keyword(s) antibodies
aptamers
nanobodies
proteins
proteome
reagents
Summary This planet is home to countless species, some more well-known than the others. While we have developed many techniques to be able to interrogate some of the “omics”, proteomics is becoming recognized as a very important part of the puzzle, given how important the protein is as a functional part of the cell. Within human health, the proteome is fairly well-established, with numerous reagents being available to decipher cellular pathways. Recent research advancements have assisted in characterizing the proteomes of some model (non-human) species, however, in many other species, we are only just touching the surface. This review considers three main reagent classes—antibodies, aptamers, and nanobodies—as a means of continuing to investigate the proteomes of non-model species without the complications of understanding the full protein signature of a species. Considerations of ease of production, potential applications, and the necessity for producing a new reagent depending on homology are presented.
Language eng
DOI 10.3390/ijms21072485
Indigenous content off
Field of Research 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136170

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.