Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: A systematic review and meta-analysis Mekonnen, Alemayehu, McLachlan, AJ and Brien, JAE 2016, Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: A systematic review and meta-analysis, BMJ Open, vol. 6, no. 2, pp. 1-14, doi: 10.1136/bmjopen-2015-010003. Attached Files Name Description MIMEType Size Downloads mekonnen-effectiveness-2015.pdf Published version application/pdf 1.75MB 47 Title Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: A systematic review and meta-analysis Author(s) Mekonnen, Alemayehu orcid.org/0000-0002-6826-4817 McLachlan, AJ Brien, JAE Journal name BMJ Open Volume number 6 Issue number 2 Article ID e010003 Start page 1 End page 14 Total pages 14 Publisher BMJ Place of publication London, Eng. Publication date 2016-02-23 ISSN 2044-6055 Keyword(s) Medication reconciliation medication discrepancies medication errors medication review pharmacists Summary Objectives: Pharmacists play a role in providing medication reconciliation. However, data on effectiveness on patients' clinical outcomes appear inconclusive. Thus, the aim of this study was to systematically investigate the effect of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions. Design: Systematic review and meta-analysis. Methods: We searched PubMed, MEDLINE, EMBASE, IPA, CINHAL and PsycINFO from inception to December 2014. Included studies were all published studies in English that compared the effectiveness of pharmacist-led medication reconciliation interventions to usual care, aimed at improving medication reconciliation programmes. Meta-analysis was carried out using a random effects model, and subgroup analysis was conducted to determine the sources of heterogeneity. Results: 17 studies involving 21 342 adult patients were included. Eight studies were randomised controlled trials (RCTs). Most studies targeted multiple transitions and compared comprehensive medication reconciliation programmes including telephone followup/home visit, patient counselling or both, during the first 30 days of follow-up. The pooled relative risks showed a more substantial reduction of 67%, 28% and 19% in adverse drug event-related hospital revisits (RR 0.33; 95% CI 0.20 to 0.53), emergency department (ED) visits (RR 0.72; 95% CI 0.57 to 0.92) and hospital readmissions (RR 0.81; 95% CI 0.70 to 0.95) in the intervention group than in the usual care group, respectively. The pooled data on mortality (RR 1.05; 95% CI 0.95 to 1.16) and composite readmission and/or ED visit (RR 0.95; 95% CI 0.90 to 1.00) did not differ among the groups. There was significant heterogeneity in the results related to readmissions and ED visits, however. Subgroup analyses based on study design and outcome timing did not show statistically significant results. Conclusion: Pharmacist-led medication reconciliation programmes are effective at improving post-hospital healthcare utilisation. This review supports the implementation of pharmacist-led medication reconciliation programmes that include some component aimed at improving medication safety. Language eng DOI 10.1136/bmjopen-2015-010003 Indigenous content off Field of Research 1103 Clinical Sciences 1117 Public Health and Health Services 1199 Other Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30136653 Document type: Journal Article Collections: Faculty of Health Open Access Collection Institute for Health Transformation Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 11 May 2020, 12:36:30 EST Tue, 12 May 2020, 05:02:02 EST Tue, 12 May 2020, 08:06:07 EST Sat, 16 Jan 2021, 05:05:48 EST Thu, 21 Jan 2021, 14:18:56 EST Thu, 21 Jan 2021, 14:21:24 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 153 times in Scopus Search Google Scholar Access Statistics: 48 Abstract Views, 47 File Downloads  -  Detailed Statistics Created: Mon, 11 May 2020, 12:36:30 EST

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