Short- and long-term outcomes in infective endocarditis patients: A systematic review and meta-analysis Abegaz, TM, Bahagavathula, AS, Gebreyohannes, EA, Mekonnen, Alemayehu and Abebe, TB 2017, Short- and long-term outcomes in infective endocarditis patients: A systematic review and meta-analysis, BMC Cardiovascular Disorders, vol. 17, no. 1, pp. 1-12, doi: 10.1186/s12872-017-0729-5. Attached Files Name Description MIMEType Size Downloads mekonnen-shortandlong-2017.pdf Published version application/pdf 1.83MB 12 Title Short- and long-term outcomes in infective endocarditis patients: A systematic review and meta-analysis Author(s) Abegaz, TM Bahagavathula, AS Gebreyohannes, EA Mekonnen, Alemayehu orcid.org/0000-0002-6826-4817 Abebe, TB Journal name BMC Cardiovascular Disorders Volume number 17 Issue number 1 Article ID 291 Start page 1 End page 12 Total pages 12 Publisher BMC Place of publication London, Eng. Publication date 2017-12-12 ISSN 1471-2261 Keyword(s) Infective endocarditis Long-term mortality Meta-analysis Short-term mortality Summary Background: Despite advances in medical knowledge, technology and antimicrobial therapy, infective endocarditis (IE) is still associated with devastating outcomes. No reviews have yet assessed the outcomes of IE patients undergoing short- and long-term outcome evaluation, such as all-cause mortality and IE-related complications. We conducted a systematic review and meta-analysis to examine the short- and long-term mortality, as well as IE-related complications in patients with definite IE. Methods: A computerized systematic literature search was carried out in PubMed, Scopus and Google Scholar from 2000 to August, 2016. Included studies were published studies in English that assessed short-and long-term mortality for adult IE patients. Pooled estimations with 95% confidence interval (CI) were calculated with DerSimonian-Laird (DL) random-effects model. Sensitivity and subgroup analyses were also performed. Publication bias was evaluated using inspection of funnel plots and statistical tests. Results: Twenty five observational studies (retrospective, 14; prospective, 11) including 22,382 patients were identified. The overall pooled mortality estimates for IE patients who underwent short- and long-term follow-up were 20% (95% CI: 18.0–23.0, P < 0.01) and 37% (95% CI: 27.0–48.0, P < 0.01), respectively. The pooled prevalence of cardiac complications in patients with IE was found to be 39% (95%CI: 32.0–46.0) while septic embolism and renal complications accounted for 25% (95% CI: 20.0–31) and 19% (95% CI: 14.0–25.0) (all P < 0.01), respectively. Conclusion: Irrespective of the follow-up period, a significantly higher mortality rate was reported in IE patients, and the burden of IE-related complications were immense. Further research is needed to assess the determinants of overall mortality in IE patients, as well as well-designed observational studies to conform our results. Language eng DOI 10.1186/s12872-017-0729-5 Indigenous content off Field of Research 1102 Cardiorespiratory Medicine and Haematology HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2017, The Author(s) Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30136677 Document type: Journal Article Collections: Faculty of Health Open Access Collection Institute for Health Transformation Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 11 May 2020, 12:45:10 EST Tue, 12 May 2020, 05:02:28 EST Tue, 12 May 2020, 08:06:53 EST Sat, 16 Jan 2021, 05:05:59 EST Tue, 19 Jan 2021, 08:52:59 EST Tue, 19 Jan 2021, 08:55:22 EST Sat, 06 Mar 2021, 01:34:05 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 16 times in Scopus Search Google Scholar Access Statistics: 16 Abstract Views, 12 File Downloads  -  Detailed Statistics Created: Mon, 11 May 2020, 12:45:10 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.