Epigenetic influences on neurodevelopment at 11 years of age: protocol for the longitudinal peri/postnatal epigenetic twins study at 11 years of age (PETS@11)

Leong, Pamela, Loke, Yuk Jing, Saffery, Richard, Silk, Tim, Burnett, Alice, Josev, Elisha, Scurrah, Katrina, Theda, Christiane, Czajko, Anna, Pua, Emmanuel PK, Seal, Marc L and Craig, Jeffrey M 2019, Epigenetic influences on neurodevelopment at 11 years of age: protocol for the longitudinal peri/postnatal epigenetic twins study at 11 years of age (PETS@11), Twin research and human genetics, vol. 22, no. 6, Special Issue 6: Twin family registries worldwide: An important resource for scientific research, pp. 446-453, doi: 10.1017/thg.2019.120.

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Title Epigenetic influences on neurodevelopment at 11 years of age: protocol for the longitudinal peri/postnatal epigenetic twins study at 11 years of age (PETS@11)
Author(s) Leong, Pamela
Loke, Yuk Jing
Saffery, Richard
Silk, TimORCID iD for Silk, Tim orcid.org/0000-0002-7290-512X
Burnett, Alice
Josev, Elisha
Scurrah, Katrina
Theda, Christiane
Czajko, Anna
Pua, Emmanuel PK
Seal, Marc L
Craig, Jeffrey MORCID iD for Craig, Jeffrey M orcid.org/0000-0003-3979-7849
Journal name Twin research and human genetics
Volume number 22
Issue number 6
Season Special Issue 6: Twin family registries worldwide: An important resource for scientific research
Start page 446
End page 453
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2019-12
ISSN 1832-4274
1839-2628
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Obstetrics & Gynecology
longitudinal
epigenetics
neurodevelopment
prenatal
postnatal
adolescence
twins
METHYLATION
CHILDREN
FAMINE
EXPOSURE
PROFILE
FETAL
LIFE
Summary Neurodevelopment is sensitive to genetic and pre/postnatal environmental influences. These effects are likely mediated by epigenetic factors, yet current knowledge is limited. Longitudinal twin studies can delineate the link between genetic and environmental factors, epigenetic state at birth and neurodevelopment later in childhood. Building upon our study of the Peri/postnatal Epigenetic Twin Study (PETS) from gestation to 6 years of age, here we describe the PETS 11-year follow-up in which we will use neuroimaging and cognitive testing to examine the relationship between early-life environment, epigenetics and neurocognitive outcomes in mid-childhood. Using a within-pair twin model, the primary aims are to (1) identify early-life epigenetic correlates of neurocognitive outcomes; (2) determine the developmental stability of epigenetic effects and (3) identify modifiable environmental risk factors. Secondary aims are to identify factors influencing gut microbiota between 6 and 11 years of age to investigate links between gut microbiota and neurodevelopmental outcomes in mid-childhood. Approximately 210 twin pairs will undergo an assessment at 11 years of age. This includes a direct child cognitive assessment, multimodal magnetic resonance imaging, biological sampling, anthropometric measurements and a range of questionnaires on health and development, behavior, dietary habits and sleeping patterns. Data from complementary data sources, including the National Assessment Program - Literacy and Numeracy and the Australian Early Development Census, will also be sought. Following on from our previous focus on relationships between growth, cardiovascular health and oral health, this next phase of PETS will significantly advance our understanding of the environmental interactions that shape the developing brain.
Language eng
DOI 10.1017/thg.2019.120
Indigenous content off
Field of Research 1114 Paediatrics and Reproductive Medicine
1103 Clinical Sciences
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136729

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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