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The value of twins for health and medical research: a third of a century of progress

Craig, Jeffrey M., Calais-Ferreira, Lucas, Umstad, Mark P. and Buchwald, Dedra 2020, The value of twins for health and medical research: a third of a century of progress, Twin research and human genetics, vol. 23, no. 1, pp. 8-15, doi: 10.1017/thg.2020.4.

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Title The value of twins for health and medical research: a third of a century of progress
Author(s) Craig, Jeffrey M.ORCID iD for Craig, Jeffrey M. orcid.org/0000-0003-3979-7849
Calais-Ferreira, Lucas
Umstad, Mark P.
Buchwald, Dedra
Journal name Twin research and human genetics
Volume number 23
Issue number 1
Start page 8
End page 15
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2020-02
ISSN 1832-4274
1839-2628
Keyword(s) Twins
environment
genetics
medical research
statistical models
stem cells
Summary In 1984, Hrubec and Robinette published what was arguably the first review of the role of twins in medical research. The authors acknowledged a growing distinction between two categories of twin studies: Those aimed at assessing genetic contributions to disease and those aimed at assessing environmental contributions while controlling for genetic variation. They concluded with a brief section on recently founded twin registries that had begun to provide unprecedented access to twins for medical research. Here we offer an overview of the twin research that, in our estimation, best represents the field has progress since 1984. We start by summarizing what we know about twinning. We then focus on the value of twin study designs to differentiate between genetic and environmental influences on health and on emerging applications of twins in multiple areas of medical research. We finish by describing how twin registries and networks are accelerating twin research worldwide.
Language eng
DOI 10.1017/thg.2020.4
Indigenous content off
Field of Research 1114 Paediatrics and Reproductive Medicine
1103 Clinical Sciences
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136813

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.