No obvious impact of caesarean delivery on childhood allergic outcomes: findings from Australian cohorts

Liao, Zijun, Lamb, Karen E, Burgner, David, Ranganathan, Sarath, Miller, Jessica E, Koplin, Jennifer J, Dharmage, Shyamali C, Lowe, Adrian J, Ponsonby, Anne-Louise, Tang, Mimi LK, Allen, Katrina J, Wake, Melissa and Peters, Rachel L 2020, No obvious impact of caesarean delivery on childhood allergic outcomes: findings from Australian cohorts, Archives of disease in childhood, vol. 105, no. 7, pp. 664-670, doi: 10.1136/archdischild-2019-317485.

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Title No obvious impact of caesarean delivery on childhood allergic outcomes: findings from Australian cohorts
Author(s) Liao, Zijun
Lamb, Karen EORCID iD for Lamb, Karen E orcid.org/0000-0001-9782-8450
Burgner, David
Ranganathan, Sarath
Miller, Jessica E
Koplin, Jennifer J
Dharmage, Shyamali C
Lowe, Adrian J
Ponsonby, Anne-Louise
Tang, Mimi LK
Allen, Katrina J
Wake, Melissa
Peters, Rachel L
Journal name Archives of disease in childhood
Volume number 105
Issue number 7
Start page 664
End page 670
Total pages 7
Publisher BMJ
Place of publication London, Eng.
Publication date 2020-06-19
ISSN 0003-9888
1468-2044
Keyword(s) allergy
caesarean
epidemiology
respiratory
Summary Background and objective As caesarean delivery and childhood allergy continue to rise, their inter-relationships may change. We examined whether caesarean delivery predicts allergic disease and impaired lung function in two contemporary harmonised population-based cohorts.MethodsParent-reported asthma and eczema data were drawn from two prospective Australian infant cohorts, HealthNuts (n=5276, born 2006–2010) and the Longitudinal Study of Australian Children (LSAC, n=5107, born 2003–2004) at age 6–7 years, and spirometric lung function from LSAC’s Child Health CheckPoint (n=1756) at age 11–12 years. Logistic regression estimated associations between delivery mode and current asthma and eczema at 6–7 years, and linear regression examined lung function at 11–12 years. Models were adjusted for potential confounding factors.ResultsComplete case analysis included 3135 HealthNuts and 3654 LSAC children (32.2% and 30.9% born by caesarean, respectively). An association was evident between caesarean delivery and asthma at age 6–7 years in HealthNuts (adjusted OR (aOR) 1.25, 95% CI 1.00 to 1.57) but not in LSAC (aOR 1.05, 95% CI 0.86 to 1.28), while neither study showed clear associations with eczema (HealthNuts: aOR 1.09, 95% CI 0.88 to 1.35; LSAC: aOR 0.89, 95% CI 0.69 to 1.15). Spirometric lung function parameters at age 11–12 years were similar by delivery mode. Associations were not modified by duration of breast feeding, maternal history of asthma/eczema, childcare attendance, number of older siblings or pet exposure.ConclusionsIn two unselected populations using harmonised protocols, the likely association of caesarean delivery with developing childhood allergy was small.
Language eng
DOI 10.1136/archdischild-2019-317485
Indigenous content off
Field of Research 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
1117 Public Health and Health Services
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136834

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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