High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men

Parker, Lewan, Morrison, Dale J., Beti, Andrew C., Roberts-Thomson, Katherine, Kaur, Gunveen, Wadley, Glenn D., Sha, Christopher S. and Kesk, Michelle A. 2020, High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men, American Journal of Physiology - Endocrinology and Metabolism, vol. 318, no. 6, pp. E1014-E1021, doi: 10.1152/AJPENDO.00540.2019.

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Title High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men
Author(s) Parker, LewanORCID iD for Parker, Lewan orcid.org/0000-0002-5372-1851
Morrison, Dale J.
Beti, Andrew C.
Roberts-Thomson, Katherine
Kaur, GunveenORCID iD for Kaur, Gunveen orcid.org/0000-0002-6250-0495
Wadley, Glenn D.
Sha, Christopher S.
Kesk, Michelle A.
Journal name American Journal of Physiology - Endocrinology and Metabolism
Volume number 318
Issue number 6
Start page E1014
End page E1021
Total pages 8
Publisher American Physiological Society
Place of publication Rockville, Md.
Publication date 2020-06
ISSN 0193-1849
1522-1555
Keyword(s) capillaries
hyperglycemia
microvascular
vascular dysfunction
Summary Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF), which may contribute to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load would prevent postprandial MBF dysfunction. Ten healthy young men (age, 27 yr [24, 30], mean with lower and upper bounds of the 95% confidence interval; height, 180 cm [174, 185]; weight, 77 kg [70, 84]) ingested a high-glucose (1.1 g/kg glucose) mixed-nutrient meal (10 kcal/kg; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound, and thigh MBF was measured via contrast-enhanced ultrasound, before meal ingestion and 1 h and 2 h postprandially. Blood glucose and plasma insulin were measured at baseline and every 15 min throughout the 2-h postprandial period. Compared with baseline, thigh muscle microvascular blood volume, velocity, and flow were significantly impaired at 60 min postprandial (−25%, −27%, and −46%, respectively; all P < 0.05) and to a greater extent at 120 min postprandial (−37%, −46%, and −64%; all P < 0.01). Heart rate and femoral arterial diameter, blood velocity, and blood flow were significantly increased at 60 min and 120 min postprandial (all P < 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction ( R2= 0.742; P < 0.001). Ingestion of a high-glucose mixed-nutrient meal impairs MBF in healthy individuals for up to 2 h postprandial
Language eng
DOI 10.1152/AJPENDO.00540.2019
Indigenous content off
Field of Research 110306 Endocrinology
06 Biological Sciences
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136860

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