High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men Parker, Lewan, Morrison, Dale J., Beti, Andrew C., Roberts-Thomson, Katherine, Kaur, Gunveen, Wadley, Glenn D., Sha, Christopher S. and Kesk, Michelle A. 2020, High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men, American Journal of Physiology - Endocrinology and Metabolism, vol. 318, no. 6, pp. E1014-E1021, doi: 10.1152/AJPENDO.00540.2019. Attached Files Name Description MIMEType Size Downloads Title High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men Author(s) Parker, Lewan orcid.org/0000-0002-5372-1851 Morrison, Dale J. Beti, Andrew C. Roberts-Thomson, Katherine Kaur, Gunveen orcid.org/0000-0002-6250-0495 Wadley, Glenn D. Sha, Christopher S. Kesk, Michelle A. Journal name American Journal of Physiology - Endocrinology and Metabolism Volume number 318 Issue number 6 Start page E1014 End page E1021 Total pages 8 Publisher American Physiological Society Place of publication Rockville, Md. Publication date 2020-06 ISSN 0193-1849 1522-1555 Keyword(s) capillaries hyperglycemia microvascular vascular dysfunction Summary Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF), which may contribute to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load would prevent postprandial MBF dysfunction. Ten healthy young men (age, 27 yr [24, 30], mean with lower and upper bounds of the 95% confidence interval; height, 180 cm [174, 185]; weight, 77 kg [70, 84]) ingested a high-glucose (1.1 g/kg glucose) mixed-nutrient meal (10 kcal/kg; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound, and thigh MBF was measured via contrast-enhanced ultrasound, before meal ingestion and 1 h and 2 h postprandially. Blood glucose and plasma insulin were measured at baseline and every 15 min throughout the 2-h postprandial period. Compared with baseline, thigh muscle microvascular blood volume, velocity, and flow were significantly impaired at 60 min postprandial (−25%, −27%, and −46%, respectively; all P < 0.05) and to a greater extent at 120 min postprandial (−37%, −46%, and −64%; all P < 0.01). Heart rate and femoral arterial diameter, blood velocity, and blood flow were significantly increased at 60 min and 120 min postprandial (all P < 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction ( R2 = 0.742; P < 0.001). Ingestion of a high-glucose mixed-nutrient meal impairs MBF in healthy individuals for up to 2 h postprandial Language eng DOI 10.1152/AJPENDO.00540.2019 Indigenous content off Field of Research 110306 Endocrinology 06 Biological Sciences 11 Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30136860 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 11 May 2020, 13:59:14 EST Tue, 12 May 2020, 05:05:34 EST Tue, 12 May 2020, 08:11:34 EST Sat, 27 Jun 2020, 02:31:47 EST Mon, 28 Sep 2020, 15:22:11 EST Mon, 28 Sep 2020, 15:26:15 EST Mon, 28 Sep 2020, 15:33:01 EST Tue, 29 Sep 2020, 13:42:53 EST Sat, 14 Nov 2020, 01:32:12 EST Filtered Full Citation counts:   Cited 4 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 72 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 11 May 2020, 13:59:14 EST

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