In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers

Bell, David R., Weber, Jeffrey K., Yin, Wang, Huynh, Tien, Duan, Wei and Zhou, Ruhong 2020, In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers, Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 15, pp. 8486-8493, doi: 10.1073/pnas.1913242117.

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Title In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
Author(s) Bell, David R.
Weber, Jeffrey K.
Yin, Wang
Huynh, Tien
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Zhou, Ruhong
Journal name Proceedings of the National Academy of Sciences of the United States of America
Volume number 117
Issue number 15
Start page 8486
End page 8493
Total pages 8
Publisher National Academy of Sciences
Place of publication Washington, D.C.
Publication date 2020-04-14
ISSN 0027-8424
1091-6490
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
RNA aptamer
rational design
molecular dynamics
isothermal titration calorimetry
epithelial cellular adhesion molecule
STRUCTURE PREDICTION
WEB SERVER
EPCAM
PROTEIN
DOCKING
CATUMAXOMAB
MECHANISMS
DYNAMICS
ASCITES
BINDING
Language eng
DOI 10.1073/pnas.1913242117
Indigenous content off
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30136926

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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