Importance of particle size and shape on the tensile strength distribution and de-agglomeration of cohesive powders

Das, Shyamal C., Behara, Srinivas Ravinda Babu, Morton, David A.V., Larson, Ian and Stewart, Peter J. 2013, Importance of particle size and shape on the tensile strength distribution and de-agglomeration of cohesive powders, Powder Technology, vol. 249, pp. 297-303, doi: 10.1016/j.powtec.2013.08.034.

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Title Importance of particle size and shape on the tensile strength distribution and de-agglomeration of cohesive powders
Author(s) Das, Shyamal C.
Behara, Srinivas Ravinda Babu
Morton, David A.V.ORCID iD for Morton, David A.V. orcid.org/0000-0002-1491-6517
Larson, Ian
Stewart, Peter J.
Journal name Powder Technology
Volume number 249
Start page 297
End page 303
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013
ISSN 0032-5910
1873-328X
Keyword(s) De-agglomeration
Agglomerate strength
Size
Shape
Intermediate lactose
Dry powder inhaler
Summary Purpose: The purpose of the study was to understand the role of particle size and shape changes in modifying agglomerate strength distribution and de-agglomeration of cohesive lactose powders. Methods: The relative de-agglomeration of three lactoses of different particle size distributions (Lactohale 201 or LH201, Lactohale 210 or LH210 and Lactohale 220 or LH220) was determined from laser diffraction particle sizing of the aerosol plume at different air flow rates. The agglomerate strength distributions were estimated by Monte Carlo simulation using the primary particle size, work of cohesion and tapped density distributions determined by laser diffraction, inverse gas chromatography and tapping apparatus, respectively. The morphology and particle shape parameters were determined by scanning electron microscopy and the Morphologi G3. Results: The estimated agglomerate strength correlated well with the de-agglomeration of all lactose samples at different air flow rates. While the work of cohesion of the lactose samples was not significantly different, the packing fraction was dependent on the proportion and shape of intermediate-sized, cohesive particles between 5.4 and 14. μm. For example, while the proportion of particles <. 5.4. μm was similar for all lactose samples, the proportion of intermediate-sized, cohesive particles increased in the order of LH201. <. LH210. <. LH220. The intermediate-sized, cohesive particles were more elongated than the <. 5.4. μm fraction and the extent of elongation of the lactose samples increased in the order of LH220. >. LH210. >. LH201. Conclusion: The study reinforced the role of agglomerate strength distributions in understanding de-agglomeration of cohesive materials. Modification of particle size distributions and shape characteristics contributed to the agglomerate strength changes in the lactose samples. The study enhanced the fundamental understanding of powder de-agglomeration and provided strategic approaches that could be used to improve inhalation product performance. © 2013 Elsevier B.V.
Language eng
DOI 10.1016/j.powtec.2013.08.034
Indigenous content off
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30137023

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