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Non-invasive delivery of therapeutics into the brain: The potential of aptamers for targeted delivery

Bukari, B, Samarasinghe, Rasika, Noibanchong, J and Shigdar, Sarah 2020, Non-invasive delivery of therapeutics into the brain: The potential of aptamers for targeted delivery, Biomedicines, vol. 8, no. 5, pp. 1-20, doi: 10.3390/BIOMEDICINES8050120.

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Title Non-invasive delivery of therapeutics into the brain: The potential of aptamers for targeted delivery
Author(s) Bukari, B
Samarasinghe, RasikaORCID iD for Samarasinghe, Rasika orcid.org/0000-0002-3669-0985
Noibanchong, J
Shigdar, SarahORCID iD for Shigdar, Sarah orcid.org/0000-0001-8084-8447
Journal name Biomedicines
Volume number 8
Issue number 5
Article ID 120
Start page 1
End page 20
Total pages 20
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2020
ISSN 2227-9059
2227-9059
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Pharmacology & Pharmacy
Research & Experimental Medicine
antibody
aptamer
blood-brain barrier
brain pathology
drug delivery
non-invasive
SELEX
CELL ADHESION MOLECULE
PHASE-II TRIAL
DRUG-DELIVERY
HIGH-AFFINITY
TRANSFERRIN RECEPTOR
MONOCLONAL-ANTIBODY
FOCUSED ULTRASOUND
BARRIER DISRUPTION
BREAST-CANCER
RNA APTAMER
antibody, aptamer, blood-brain barrier, brain pathology, drug delivery, non-invasive, SELEX
Summary The blood-brain barrier (BBB) is a highly specialised network of blood vessels that effectively separates the brain environment from the circulatory system. While there are benefits, in terms of keeping pathogens from entering the brain, the BBB also complicates treatments of brain pathologies by preventing efficient delivery of macromolecular drugs to diseased brain tissue. Although current non-invasive strategies of therapeutics delivery into the brain, such as focused ultrasound and nanoparticle-mediated delivery have shown various levels of successes, they still come with risks and limitations. This review discusses the current approaches of therapeutic delivery into the brain, with a specific focus on non-invasive methods. It also discusses the potential for aptamers as alternative delivery systems and several reported aptamers with promising preliminary results.
Language eng
DOI 10.3390/BIOMEDICINES8050120
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30137538

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.